ArticleArthritis & rheumatology (Hoboken, N.J.)2025
Associations and Diagnostic Accuracy of Ultrasound Features in Knee Osteoarthritis: Cross-Sectional Results From a Large Community-Based Cohort.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Prevalence of knee radiographic and symptomatic osteoarthritis and ultrasound features across sex and body mass index groups: The Johnston County Health Study.Osteoarthritis and cartilage · 2026Article
- Reply.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Musculoskeletal Ultrasound and Protein-Based Hydrogels: Novel Approaches for the Diagnosis and Treatment of Sports Injuries.Polymers · 2026Review
- Cross-sectional associations of radiographic multiple joint osteoarthritis and symptoms, laboratory values and the gut microbiota: A multimodal study in humans and pet dogs.Osteoarthritis and cartilage open · 2025Article
- Patterns of Shared Variation in Knee Ultrasound for Osteoarthritis: A Machine Learning Approach.Osteoarthritis imaging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveOur study objectives were (1) to determine associations among ultrasound (US) features of knee osteoarthritis (KOA), radiographic KOA (rKOA), and patient-reported symptoms and (2) to determine diagnostic accuracy of US definitions for rKOA, in a community-based cohort.
methodsParticipants enrolled in the Johnston County Health Study (JoCoHS; 2019-2024, n = 902) provided demographics, comorbidities, clinical features, and symptoms, along with imaging with standardized acquisition and scoring protocols. Logistic regression models provided odds ratios adjusted for age, sex, race, ethnicity, body mass index (BMI), education level, comorbidities, and knee injury for associations among US features and KOA outcomes. Diagnostic accuracy was assessed using standard metrics with rKOA as the gold standard.
resultsComplete imaging data were available for 861 participants (1,711 knees): 34% men, 25% Black, 10% Hispanic, mean age 55 years, and mean BMI 33. Half of knees were symptomatic, one-third had rKOA, and one in five had symptomatic rKOA. US-identified osteophytes, effusion, meniscal extrusion, cartilage damage, calcium crystals, and popliteal cysts were associated with KOA outcomes. A US definition including both mild osteophytes and mild cartilage damage gave an area under the receiver operating characteristic curve of 0.76 for diagnosing rKOA (validated in an external cohort).
conclusionWe identified common US features in participants with and without KOA, along with significant associations between US features and rKOA, symptomatic rKOA, and symptoms. US-based diagnosis of rKOA shows promise for general use. US is a valuable and accessible modality for assessment of knee OA features in clinical and research settings, including those with limited resources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.