ArticleCirculation. Arrhythmia and electrophysiology2025
Oxidative Stress Causes Mitochondrial and Electrophysiologic Dysfunction to Promote Atrial Fibrillation in
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Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
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Who cites it
10 citing papers in PubMed.
- PITX2C deficiency promotes arrhythmogenic remodelling via oxidative stress in atrial myocytes.Journal of molecular and cellular cardiology plus · 2026Article
- Synergistic effects of nicotine and hyperlipidemia induce cardiac damage via dynamic cardiomyocyte-based biosensing.Microsystems & nanoengineering · 2026Article
- Divergent mitochondrial and fibrotic signatures in atrial fibrillation: insights from organoids and GEO data.Cardiovascular diabetology · 2026Article
- Mitochondrial dysfunction drives ZBP1-mediated PANoptosis to increase the susceptibility of heart failure with preserved ejection fraction-associated atrial fibrillation.Journal of advanced research · 2026Article
- Association Between Hemoglobin Glycation Index and Mortality in Critically Ill Patients With Atrial Fibrillation: A Retrospective Cohort Study.Clinical cardiology · 2026Article
- Article
- Targeting Nrf3-Pitx2-ROS axis represents a promising therapeutic strategy for myocardial infarction.MedScience · 2026Article
- Oxidative Stress, Mitochondrial Homeostasis, and Sirtuins in Atrial Fibrillation.International journal of molecular sciences · 2025Review
- PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.Nature communications · 2025Article
- Single-Nucleotide Polymorphisms,International journal of molecular sciences · 2025Review
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Authors and funding
16 authors.
Tuerdi Subati *Department of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0001-7779-9277
Kyungsoo Kim *Department of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0003-2869-0659
Zhenjiang YangDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-9315-154X
Matthew B MurphyDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.
Joseph C Van AmburgDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-1410-6995
Isis L ChristopherDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-0075-094X
Owen P DoughertyDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-9404-0235
Kaylen K WoodallDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0001-7347-9663
Charles D SmartDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0003-0391-3916
Joyce E JohnsonDepartment of Pathology, Microbiology, and Immunology (J.E.J., A.B.F.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-3680-4372
Agnes B FogoDepartment of Pathology, Microbiology, and Immunology (J.E.J., A.B.F.), Vanderbilt Univ School of Medicine, Nashville, TN.
Venkataraman AmarnathDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0001-5766-069X
Vineet AgrawalDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-8457-6722
Joey V BarnettDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-8757-4976
Jeffrey E SaffitzDepartment of Pathology, Beth Israel Deaconess Medical Center, Boston, MA (J.E.S.).ORCID 0000-0001-8568-9457
Katherine T MurrayDepartment of Medicine (T.S., K.K., Z.Y., M.B.M., J.C.V.A., I.L.C., O.P.D., K.K.W., C.D.S., V. Amarnath, V. Agrawal, J.V.B., K.T.M.), Vanderbilt Univ School of Medicine, Nashville, TN.ORCID 0000-0002-1342-4457
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcela Brissova · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MPreamyloid Oligomers and Susceptibility to Atrial FibrillationR01HL096844 · NHLBI · VANDERBILT UNIVERSITY · PI MURRAY, KATHERINE T · 2010 to 2014
$1.9MLSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560kBLRD VA IK2 BX005828NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NHLBI NIH HHS R01 HL096844NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIH HHS S10 OD021630
Abstract
backgroundThe strongest genetic risk factors for atrial fibrillation (AF) are DNA variants on chromosome 4q25 near the transcription factor gene
methods
results
conclusionsThese results demonstrate a critical role for lipid dicarbonyl mediators of oxidative stress in the proarrhythmic remodeling and AF susceptibility that occurs with
Indexed as
Atrial FibrillationHomeodomain ProteinsMitochondria, HeartMyocytes, CardiacOxidative StressTranscription FactorsAction PotentialsAnimalsDisease Models, AnimalHeart RateHomeobox Protein PITX2MaleMiceMice, Inbred C57BLReactive Oxygen SpeciesHomeobox Protein PITX2Homeodomain ProteinsReactive Oxygen SpeciesTranscription Factorsatrial fibrillationelectrophysiologyisolevuglandinslipidsmitochondriaoxidative stress
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.