Evidence map›Paper›PMID 39990227›Full record

ArticleTheranostics2025

Neurotrophic factor-α1/carboxypeptidase E controls progression and reversal of Alzheimer's disease pathogenesis in mice.

Fang-Cheng Fan, Li-Ming Liu, Mei Guo, Yang Du, Yue-Wen Chen, Y Peng Loh, Yong Cheng

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Predicted molecules followed by experimental validation for protecting human neurons from oxidative stress-induced cytotoxicity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Neuroinflammation Markers in Tear Fluid of Mild Alzheimer's Disease.Journal of molecular neuroscience : MN · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fang-Cheng FanDepartment of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong, China, 528000.
Li-Ming LiuInstitute of National Security, Minzu University of China, 27 Zhongguancun South St, Haidian District, Beijing, China, 100081.
Mei GuoKey Laboratory of Ethnomedicine of Ministry of Education, Center for Translational Neuroscience, School of Pharmacy, Minzu University of China, 27 Zhongguancun South St, Haidian District, Beijing, China, 100081.
Yang DuKey Laboratory of Ethnomedicine of Ministry of Education, Center for Translational Neuroscience, School of Pharmacy, Minzu University of China, 27 Zhongguancun South St, Haidian District, Beijing, China, 100081.
Yue-Wen ChenChinese Academy of Sciences Key Laboratory of Brain Connectome and Manipulation, Shenzhen Key Laboratory of Translational Research for Brain Diseases, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, 1068 Xueyuan Avenue, Xili Shenzhen University City, Nanshan District, Shenzhen, Guangdong, China, 518055.
Y Peng LohSection on Cellular Neurobiology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland, United States of America, 20892.
Yong ChengKey Laboratory of Ethnomedicine of Ministry of Education, Center for Translational Neuroscience, School of Pharmacy, Minzu University of China, 27 Zhongguancun South St, Haidian District, Beijing, China, 100081.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseCarboxypeptidase HAmyloid beta-PeptidesAnimalsDisease Models, AnimalDisease ProgressionHippocampusHumansMaleMiceMice, TransgenicMicrogliaPlaque, AmyloidAmyloid beta-PeptidesCarboxypeptidase H5xFAD MouseAlzheimer's Disease (AD)NeuroprotectionNeurotrophic Factor-α1/Carboxypeptidase E (NF-α1/CPE)Therapeutic Target

Identifiers

PMID39990227
PMCPMC11840748

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.