Evidence map›Paper›PMID 39990348›Full record

ArticlebioRxiv : the preprint server for biology2025

Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity.

Amandine Le Corf, Sarah Maesen, Clara Loyer, Juan Manuel Vazquez, M Elise Lauterbur, Lucas Sareoua, Genevieve Gray-Sandoval, Andrea Cimarelli, Carine Rey, Peter H Sudmant and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Amandine Le CorfCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.
Sarah MaesenCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.
Clara LoyerCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.
Juan Manuel VazquezDepartment of Integrative Biology, University of California, Berkeley, CA, USA.
M Elise LauterburDepartment of Biology, University of Vermont, Burlington, VT, USA.
Lucas SareouaCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.
Genevieve Gray-SandovalDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.
Andrea CimarelliCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.ORCID 0000-0003-0892-0488
Carine ReyCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.
Peter H SudmantDepartment of Integrative Biology, University of California, Berkeley, CA, USA.ORCID 0000-0002-9573-8248
David EnardDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA.ORCID 0000-0003-2634-8016
Lucie EtienneCIRI, Centre International de Recherche en Infectiologie, Inserm U1111, CNRS UMR5308, Ecole Normale Superieure de Lyon, Universite Claude Bernard Lyon 1, Univ Lyon, 69007 Lyon, France.ORCID 0000-0002-8585-7534

Funding

The evolution and diversity of mutation, molecular fidelity, and genome structureR35GM142916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Peter Heshedahl Sudmant · 2021 to 2026
$2.5M
Ancient viral threats through the lens of adaptation in human genomesR35GM142677 · NIGMS · UNIVERSITY OF ARIZONA · PI ENARD, DAVID · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM142677NIGMS NIH HHS R35 GM142916
6 · The paper itself

Abstract

Bats are asymptomatic reservoirs of several zoonotic viruses. This may result from long-term coevolution between viruses and bats, that have led to host adaptations contributing to an effective balance between strong antiviral responses with innate immune tolerance. To better understand these virus-host interactions, we combined comparative transcriptomics, phylogenomics and functional assays to characterize the evolution of bat innate immune antiviral factors. First, we stimulated the type I interferon immune pathway in

Indexed as

antiviral factorbatsChiropteraEBLV-1GBP5Guanylate-binding proteinsHIVinnate immunitymolecular arms-racepositive selectionretrovirusRhabdovirusvirus-host coevolution

Identifiers

PMID39990348
PMCPMC11844482

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.