Evidence map›Paper›PMID 39990429›Full record

ArticlebioRxiv : the preprint server for biology2025

TF2TG: an online resource mining the potential gene targets of transcription factors in

Yanhui Hu, Jonathan Rodiger, Yifang Liu, Chenxi Gao, Ying Liu, Mujeeb Qadiri, Austin Veal, Martha L Bulyk, Norbert Perrimon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0003-1494-1402
Jonathan RodigerDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Yifang LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Chenxi GaoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Ying LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0002-6419-1980
Mujeeb QadiriDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Austin VealDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Martha L BulykDivision of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3456-4555
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0001-7542-472X

Funding

Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E · 2019 to 2023
$6.8M
TRiP resources for modeling human diseaseR24OD030002 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2020 to 2023
$3.2M
Next-generation Drosophila cell lines to elucidate the cellular basis of human diseasesR24OD019847 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT, SIMCOX, AMANDA · 2017 to 2020
$2.7M
Transcriptional silencers inDrosophilaR01HG009723 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI BULYK, MARTHA L · 2017 to 2020
$2.7M
Using CRISPR technology to study the function of paralogous genesR24OD026435 · OD · HARVARD MEDICAL SCHOOL · PI BELLEN, HUGO J, PERRIMON, NORBERT · 2018 to 2021
$2.5M
Resources for functional studies in DrosophilaR24OD031952 · OD · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2022 to 2025
$2.2M
Transcriptional silencers in DrosophilaR56HG009723 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI BULYK, MARTHA L · 2024 to 2024
$692k
NCI NIH HHS P01 CA120964NHGRI NIH HHS R01 HG009723NHGRI NIH HHS R56 HG009723NIGMS NIH HHS P41 GM132087NIH HHS R24 OD019847NIH HHS R24 OD026435NIH HHS R24 OD030002NIH HHS R24 OD031952
6 · The paper itself

Abstract

Sequence-specific transcription factors (TFs) are key regulators of many biological processes, controlling the expression of their target genes through binding to the cis- regulatory regions such as promoters and enhancers. Each TF has unique DNA binding site motifs, and large-scale experiments have been conducted to characterize TF-DNA binding preferences. However, no comprehensive resource currently integrates these datasets for

Indexed as

ChIP-SeqDrosophila. TF motifprotein complextranscriptional regulationTranscription factors

Identifiers

PMID39990429
PMCPMC11844531

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.