Evidence map›Paper›PMID 39990487›Full record

ArticlebioRxiv : the preprint server for biology2025

Axonal Mechanotransduction Drives Cytoskeletal Responses to Physiological Mechanical Forces.

Grace L Swaim, Oliver V Glomb, Yi Xie, Chloe Emerson, Zhuoyuan Li, Daniel Beaudet, Adam G Hendricks, Shaul Yogev

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Grace L SwaimDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-3152-227X
Oliver V GlombDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-1762-5037
Yi XieDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0003-1936-0121
Chloe EmersonDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0003-1188-0501
Zhuoyuan LiDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.
Daniel BeaudetDepartment of Bioengineering, McGill University, Montreal, QC H3A 0E9.ORCID 0009-0001-5955-3721
Adam G HendricksDepartment of Bioengineering, McGill University, Montreal, QC H3A 0E9.ORCID 0000-0003-3635-1577
Shaul YogevDepartment of Neuroscience, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0003-2427-2142

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Patterning acentrosomal microtubule arraysR35GM133573 · NIGMS · YALE UNIVERSITY · PI Shaul Yogev · 2019 to 2026
$3.2M
NIGMS NIH HHS R35 GM133573NIH HHS P40 OD010440
6 · The paper itself

Abstract

Axons experience strong mechanical forces due to animal movement. While these forces serve as sensory cues in mechanosensory neurons, their impact on other neuron types remains poorly defined. Here, we uncover signaling that controls an axonal cytoskeletal response to external physiological forces and plays a key role in axonal integrity. Live imaging of microtubules at single-polymer resolution in a

Identifiers

PMID39990487
PMCPMC11844441

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.