Evidence map›Paper›PMID 39991102›Full record

ArticleThe EPMA journal2025

Identifying Specificity Protein 2 as a key marker for diabetic encephalopathy in the context of predictive, preventive, and personalized medicine.

Guorong Tao, Xuebao Wang, Jian Wang, Yiru Ye, Minxue Zhang, Yan Lang, Saidan Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EPMA journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guorong Tao *Laboratory Animal Center, Fudan University, Shanghai, 200032 China.
Xuebao Wang *School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325000 Zhejiang China.
Jian WangKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 China.
Yiru YeKey Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000 China.
Minxue ZhangLaboratory Animal Center, Fudan University, Shanghai, 200032 China.
Yan LangLaboratory Animal Center, Fudan University, Shanghai, 200032 China.
Saidan DingLaboratory Animal Center, Fudan University, Shanghai, 200032 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transcription factor specificity protein (SP2) regulates various cellular functions, including cell division, proliferation, invasion, metastasis, differentiation, and death; however, its role has not been studied in prominent medical conditions including diabetic encephalopathy (DE). Therefore, this study addressed its physiological function in the context of DE to also better characterize its possible use in the context of predictive, preventive, and personalized medicine (PPPM). Methods: The anti-inflammatory and anti-DE actions of SP2 were investigated using three animal models (SP2 Results: Mechanistically, SP2-knockout (SP2 Conclusions: These findings highlight SP2 as key biological targets for DE and reveal the infammation-related potential molecular mechanism of DE, which is helpful for early risk prediction and targeted prevention of DE. In conclusion, our study provides a new perspective for developing a PPPM method for managing DE patients. Supplementary Information: The online version contains supplementary material available at 10.1007/s13167-024-00394-0.

Indexed as

Db/db miceDiabetic encephalopathy (DE)Early risk predictionMorris water maze testN2A cellsNerve damageNeuroinflammationOxidative stressPredictive preventive personalized medicine (PPPM / 3PM)Primary cultured hippocampal neuronsSpecificity Protein 2 (SP2)Streptozocin-treated miceX-box binding protein 1 (XBP1)Y-maze test; SP2−/− mice

Identifiers

PMID39991102
PMCPMC11842694

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.