ArticleHeliyon2025
Appendiceal cancer in pregnancy and circulating tumor cells detection in the umbilical cord.
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Fulminant peritoneal metastasis of appendiceal mucinous adenocarcinoma during pregnancy: a case report.BMC pregnancy and childbirth · 2026Article
- Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although malignant tumors metastasizing to infant or the placenta are occasionally reported during pregnancy, the adverse effects of maternal malignant tumors on fetus have not been clarified. Due to the rarity of appendiceal cancer during pregnancy, the adverse effects of tumor on pregnancy have not been clarified. Herein, we report a 30-year-old woman who experienced appendiceal cancer (stage IVC) wherein metastatic ovarian tumor was detected during pregnancy. A bilateral salpingo-oophorectomy and partial resection of the omentum were performed at 25 weeks 6 days gestational age (GA), followed by Cesarean section at 30 weeks 1 day GA. Postpartum chemotherapy with fluorouracil, oxaliplatin, and levofolinate calcium could not sufficiently control her disease. Purpura was observed all over the infant body at birth. The neonatal disseminated intravascular coagulation score was 4 according to the scoring system used by the Japanese Society of Obstetrical, Gynecological & Neonatal Hematology, which meet the neonatal disseminated intravascular coagulation criteria. Detailed histopathological examination did not detect any cancer cells in the placenta or umbilical cord. Moreover, no other malignant abnormalities were found based on comprehensive medical evaluation of the infant. However, maternal circulating tumor cells (CTCs) were detected in both maternal and umbilical cord blood samples from the patient. Collectively, this case might be the first step into studying the circulation of CTCs through the umbilical cord via placenta and its effects on the fetal outcome; maternal malignant tumor worsened the fetal condition. More advanced analysis of CTCs in umbilical cord blood would be useful for predicting negative effects of maternal malignant tumor on infant in future.
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Registered trials
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