ArticleJournal of inflammation research2025
Combined Inflammatory Markers for Predicting Acute Exacerbations in Chronic Obstructive Pulmonary Disease With Respiratory Failure.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic Value of Multifrequency Bioelectrical Impedance Analysis in Chronic Obstructive Pulmonary Disease: Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Lactate-to-albumin ratio, C-reactive protein-to-albumin ratio, and prognostic nutritional index in acute and critical care: A focused mini-review.World journal of critical care medicine · 2026Review
- Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD.Frontiers in immunology · 2026Article
- The Role of Advanced Lung Cancer Inflammation Index in Predicting COPD Exacerbation Risks.International journal of chronic obstructive pulmonary disease · 2026Article
- Protective Effects of Qingre Sanjie Jiaonang on Pulmonary Fibrosis: A Pilot Study.Journal of inflammation research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to assess the predictive value of the neutrophil-lymphocyte ratio (NLR), C-reactive protein/albumin ratio (CAR), and serum amyloid A (SAA) in predicting acute exacerbations of chronic obstructive pulmonary disease (AECOPD) complicated by respiratory failure (RF). Methods: A retrospective study was conducted on 198 patients with AECOPD in the Respiratory Department of No. 2 People's Hospital of Fuyang City from December 2022 to May 2023. Patients were categorized into two groups: an experimental group with the presence of RF (n = 70) and a control group with no RF present (n = 128). Baseline characteristics and inflammatory marker levels were compared between the two groups, and their impact on the risk of readmission within one year was analyzed to assess the predictive value of NLR, CAR, and SAA in patients with AECOPD and RF. Results: The experimental group exhibited significantly higher levels of white blood cells, neutrophils, C-reactive protein (CRP), SAA, NLR, and CAR compared to the control group. Additionally, the experimental group had a higher one-year readmission rate, with statistically significant differences. The areas under the receiver operating characteristic (ROC) curve for NLR, CAR, and SAA in predicting AECOPD with RF were 0.705, 0.659, and 0.656, respectively. When combined, the ROC area under the curve for these three markers increased to 0.717, which was statistically significant. Conclusion: The combined assessment of NLR, CAR, and SAA offers a reliable reflection of systemic inflammation and holds predictive value for AECOPD with RF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.