ArticleJournal of inflammation research2025
Effect of Age, Sex and Season on Acute Myeloid Leukemia Clinical Characteristics: A Retrospective Study.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Development and application of machine learning models for hematological disease diagnosis using routine laboratory parameters: a user-friendly diagnostic platform.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute myeloid leukemia (AML) is a lethal malignancy of the bone marrow, characterized by rapid proliferation of immature myeloid cells, leading to insufficient hematopoiesis and immune activities. It is well known that AML is closely associated with various molecular and cytogenetic abnormalities. In addition, the long-standing view that non-genetic factors, including age, sex and season, are also associated with the occurrence and development of AML. However, effects of these factors on AML clinical characteristics remain incompletely understood. During clinical practice, we perceived an imbalance distribution of clinical characteristics (including FAB classification, gene mutations, lymphocyte-associated cytokine levels and lymphocyte-subset proportions) in different age, sex and season groups. In order to elucidate the correlations between these factors, we performed a comprehensive data collection and analysis of AML patients in our hospital from 2013 to 2023. Methods: Totally, 2798 newly diagnosed AML patients and 220 relapsed AML patients who were admitted to our hospital from January 1, 2013 to December 31, 2023 were included for analysis. Chi-square test was conducted to analyze the correlation between categorical variables. T-tests and one-way ANOVA were employed to compare mean values across two and multiple groups respectively. Mann-Whitney Results: Overall, the distribution of age, sex and season in AML patients were unbalanced. The relationships among various mutated genes had two sides, co-existence or mutual exclusivity. Additionally, the FAB classification and gene mutation status varied significantly across the subgroups. The levels of cytokines and lymphocyte subsets altered significantly in AML patients, and were associated with prognosis and gene mutations. Conclusion: Age, sex and season have shown partial correlations with AML clinical characteristics, including FAB classification, gene mutations status, lymphocyte-associated cytokine levels and lymphocyte subset proportions. We hope these findings can contribute to a deeper understanding of AML.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.