Evidence map›Paper›PMID 39992207›Full record

ArticleAging2025

Identification of senescence rejuvenation mechanism of

Yun Haeng Lee, Eun Young Jeong, Ye Hyang Kim, Ji Ho Park, Jee Hee Yoon, Yoo Jin Lee, So Hun Lee, Yeon Kyung Nam, So Yoon Cha, Jin Seong Park and 4 more

Abstract read
In one paragraph

Article in Aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yun Haeng LeeDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Eun Young JeongLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Ye Hyang KimLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Ji Ho ParkDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Jee Hee YoonDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Yoo Jin LeeDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
So Hun LeeLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Yeon Kyung NamLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
So Yoon ChaLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Jin Seong ParkLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
So Yeon KimLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Youngjoo ByunCollege of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
Song Seok ShinLife Sciences R&D Center, Hyundai Bioland co. ltd, 22, Osongsaengmyeong 2–ro, Osong–eup, Heungdeok–gu, Cheongju–si, Chungcheongbuk–do, Republic of Korea.
Joon Tae ParkDivision of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactive oxygen species (ROS) contribute to aging by mainly damaging cellular organelles and DNA. Although strategies to reduce ROS production have been proposed as important components of anti-aging therapy, effective mechanisms to lower ROS levels have not yet been identified. Here, we screened natural compounds frequently used as cosmetic ingredients to find substances that reduce ROS levels.

Indexed as

Biphenyl CompoundsCellular SenescenceLignansMagnoliaPlant ExtractsRejuvenationSkin AgingAllyl CompoundsAnimalsAntioxidantsFibroblastsHumansMiceMitochondriaPhenolsReactive Oxygen SpeciesAllyl CompoundsAntioxidantsBiphenyl CompoundshonokiolLignansPhenolsPlant ExtractsReactive Oxygen Speciesaging rejuvenationhonokiolmagnolia officinalismitochondriaROS

Identifiers

PMID39992207
PMCPMC11892931

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.