ArticleEuropean journal of medical research2025
Relationship between the geriatric nutritional risk index and sepsis in elderly critically ill patients: a retrospective cohort study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Geriatric Nutritional Risk Index and risks of all-cause, cardiovascular, and diabetes-related mortality in adults with obesity: A nationally representative cohort study.American heart journal plus : cardiology research and practice · 2026Article
- The geriatric nutritional risk index predicts short-term mortality in older patients with urosepsis: a retrospective cohort study with external validation.Frontiers in nutrition · 2026Article
- Analysis of the predictive value of 3-day cumulative energy deficit for 28-day mortality in patients with sepsis and nutritional risk: a retrospective study.Frontiers in nutrition · 2026Article
- Prognostic nutritional indices predict 60 day mortality in ICU patients with sepsis.Scientific reports · 2025Article
- Can Nutritional Screening Tools Predict the Prognosis of Critically Ill Patients with Sepsis?Medicina (Kaunas, Lithuania) · 2025Observational
- The V-shaped association between the ratio of neutrophil counts to prognostic nutritional index and 30-, 60-, and 90-day mortality in elderly critically ill patients aged 65 and older with sepsis: a retrospective study based on the MIMIC database.Frontiers in nutrition · 2025Article
- Prognostic value of the Geriatric Nutritional Risk Index in sepsis-associated acute kidney injury: a retrospective cohort study.Frontiers in nutrition · 2025Article
- The relationship between improved elderly nutritional risk index and short-term all-cause mortality in patients with urinary sepsis: a retrospective cohort study.Frontiers in nutrition · 2025Article
- The relationship between elderly nutritional risk index and short-term all-cause mortality in critically ill patients with cerebral injury: a retrospective cohort study from two cohorts.Frontiers in nutrition · 2025Article
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Abstract
objectiveTo investigate the relationship between the geriatric nutritional risk index (GNRI) and sepsis in elderly critically ill patients.
methodsWe extracted data from the MIMIC-IV database for patients aged 65 and older who were first-time admissions to the Intensive Care Unit. The GNRI, derived from serum albumin, height, and weight, served as the exposure variable. The main outcome was the occurrence of sepsis. We utilized multivariable logistic regression to evaluate the association between GNRI and sepsis. Additionally, we employed restricted cubic splines to evaluate the potential nonlinear relationship between GNRI and the incidence of sepsis.
resultsThe study included 3,535 elderly patients, with 2,005 (56.7%) developing sepsis. Septic patients had significantly lower GNRI values (median: 99 vs. 101, P = 0.021) and a higher prevalence of malnutrition risk (GNRI ≤ 98) (47.5% vs. 43.5%, P = 0.018). The analysis employing restricted cubic splines identified a U-shaped association between GNRI and sepsis (P for non-linearity = 0.004), with an inflection point at 105.4. To the left of this inflection point, GNRI was significantly negatively associated with sepsis (OR = 0.987, 95% CI 0.978-0.996, P = 0.005), while the right side showed a positive correlation (OR = 1.011, 95% CI 1.000-1.022, P = 0.044).
conclusionThe study reveals a U-shaped association between GNRI and sepsis in elderly critically ill patients. Both low and high GNRI values are associated with increased sepsis risk, with a turning point at 105.4. These findings highlight GNRI's utility as a screening tool for identifying sepsis risk in elderly ICU patients.
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