Evidence map›Paper›PMID 39995111›Full record

ArticleClinical and translational medicine2025

Kibra knockdown inhibits the aberrant Hippo pathway, suppresses renal cyst formation and ameliorates renal fibrosis in nphp1

Yichen Yang, Zhihe Xue, Jiayong Lai, Jinglan Zhang, Changmiao Pang, Jinglin Zhong, Zhanpeng Kuang, Baojuan Zou, Yaqing Liu, Liangzhong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yichen YangDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0009-0009-0463-2981
Zhihe XueDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiayong LaiDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jinglan ZhangDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Changmiao PangDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jinglin ZhongDepartment of Pediatrics, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, China.
Zhanpeng KuangDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Baojuan ZouDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yaqing LiuDepartment of Pediatrics, The First Affiliated Hospital, Gannan Medical University, Ganzhou, China.
Liangzhong SunDepartment of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Funding

National Natural Science Foundation of China 81670610Natural Science Foundation of Guangdong Province 2022A1515012307Natural Science Foundation of Guangdong Province 2024A1515013163
6 · The paper itself

Abstract

introductionNephronophthisis (NPH) is an autosomal recessive interstitial cystic kidney disease, which is the most common genetic cause of end-stage renal disease (ESRD) in childhood. The Hippo pathway is regulated by the cilium and has been suggested to be linked to NPH. The aim of the study was to investigate the involvement of Hippo pathway in the pathogenesis of nphp1 defect-associated NPH (NPH1).

methodNphp1 knockout (nphp1

resultsIn nphp1

conclusionsThe canonical Hippo pathway is aberrantly activated in nphp1-deficient conditions. Kibra may serve as a crucial upstream regulator of nphp1 deficiency-related Hippo pathway activation. Kibra upregulation and activation of the Hippo pathway are involved in the pathogenesis of NPH1. KEY POINTS: Canonical Hippo pathway activated in nphp1-deficient disease models and patients. Kibra was a key upstream molecule in regulating the activation of canonical Hippo pathway in nphp1-deficient disease models and patients and closely related to renal cyst formation and fibrosis in nphp1

Indexed as

Intracellular Signaling Peptides and ProteinsKidney Diseases, CysticAnimalsDisease Models, AnimalDogsFibrosisHippo Signaling PathwayHumansKidneyMadin Darby Canine Kidney CellsMiceMice, Inbred C57BLMice, KnockoutProtein Serine-Threonine KinasesSignal TransductionIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesHippo pathwayKibranephronophthisisnphp1renal cyst

Identifiers

PMID39995111
PMCPMC11850762

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.