Evidence map›Paper›PMID 39995666›Full record

ArticleFrontiers in immunology2025

CD38 deficiency leads to a defective short-lived transcriptomic response to chronic graft-versus-host disease induction, involving purinergic signaling-related genes and distinct transcriptomic signatures associated with lupus.

Mercedes Zubiaur, Laura C Terrón-Camero, Fernando Gordillo-González, Eduardo Andrés-León, Alicia Barroso-Del Jesús, Luz María Canet-Antequera, María M Pérez Sánchez-Cañete, África Martínez-Blanco, Marilú Domínguez-Pantoja, María Botia-Sánchez and 8 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mercedes Zubiaur *Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Laura C Terrón-CameroBioinformatics Unit, IPBLN, CSIC, Granada, Spain.
Fernando Gordillo-GonzálezBioinformatics Unit, IPBLN, CSIC, Granada, Spain.
Eduardo Andrés-LeónBioinformatics Unit, IPBLN, CSIC, Granada, Spain.
Alicia Barroso-Del JesúsGenomics, IPBLN, CSIC, Granada, Spain.
Luz María Canet-AntequeraGenomics, IPBLN, CSIC, Granada, Spain.
María M Pérez Sánchez-CañeteFlow Cytometry, IPBLN, CSIC, Granada, Spain.
África Martínez-BlancoDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Marilú Domínguez-PantojaDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
María Botia-SánchezDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Sonia Pérez-CabreraDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Nerea Bello-IglesiasDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Antonio AlcinaDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Ana-Clara Abadía-MolinaDepartment of Biochemistry, Molecular Biology and Immunology III, School of Medicine, University of Granada (UGR), Granada, Spain.
Fuencisla MatesanzDepartment of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.
Esther ZumaqueroDepartment of Microbiology, University of Alabama at Birmingham (UAB), Birmingham, AL, United States.
Ramón MerinoDepartment of Cell and Molecular Signaling, Institute of Biomedicine and Biotechnology of Cantabria (IBBTEC), University of Cantabria (UC) and CSIC, Santander, Spain.
Jaime Sancho *Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine "López-Neyra" (IPBLN), Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to elucidate the transcriptomic signatures and dysregulated pathways associated with the autoimmune response in

Indexed as

ADP-ribosyl Cyclase 1Graft vs Host DiseaseLupus Erythematosus, SystemicMembrane GlycoproteinsReceptors, PurinergicTranscriptomeAnimalsChronic DiseaseDisease Models, AnimalGene Expression ProfilingMiceMice, Inbred C57BLMice, KnockoutSignal TransductionADP-ribosyl Cyclase 1Cd38 protein, mouseMembrane GlycoproteinsReceptors, PurinergicCD38cGAS-STINGcGVHD lupus modelNLRP3-inflammasomepurinergic-signalingsenescencetranscriptome signaturetype I IFN signature

Identifiers

PMID39995666
PMCPMC11847871

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.