Evidence map›Paper›PMID 39997439›Full record

ReviewJournal of fungi (Basel, Switzerland)2025

A Review of the Biotechnological Potential of Cave Fungi: A Toolbox for the Future.

Renan N Barbosa, Maria Tamara C Felipe, Leticia F Silva, Edna A Silva, Sabrina A Silva, Polyanna N Herculano, José F S A Prazeres, Joenny M S Lima, Jadson D P Bezerra, Keila A Moreira and 2 more

Abstract readReview
In one paragraph

Review in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. IMA fungus · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Renan N BarbosaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Maria Tamara C FelipeDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.ORCID 0000-0002-1692-5476
Leticia F SilvaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Edna A SilvaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Sabrina A SilvaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Polyanna N HerculanoDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
José F S A PrazeresDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.ORCID 0000-0003-1188-035X
Joenny M S LimaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Jadson D P BezerraInstituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia 74605-050, Goiás, Brazil.ORCID 0000-0002-7782-8602
Keila A MoreiraDepartamento de Medicina Veterinária, Universidade Federal do Agreste de Pernambuco, Garanhuns 55292-270, Pernambuco, Brazil.ORCID 0000-0002-7715-9285
Oliane M C MagalhãesDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.
Cristina M Souza-MottaDepartamento de Micologia, Universidade Federal de Pernambuco, Recife 50740-600, Pernambuco, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study of the intersection between biodiversity and biotechnology has revealed a rich source of innovations. Fungi, with their vast range of morphologies and lifestyles, thrive in various habitats, including caves. With impressive metabolic characteristics, they play a key role in producing essential biotechnological compounds for various economic sectors. This paper aims to consolidate evidence on the biotechnological potential of fungi isolated from caves, highlighting the urgency of conserving and exploring these ecosystems. For this purpose, we conducted a comprehensive literature search using scientific databases (SciELO, Medline Complete, Medline/PubMed, Web of Science, Scopus (Elsevier), and Google Scholar). We adopted an interdisciplinary approach by collecting information from 22 papers published between 2013 and 2024. Based on these data, our survey revealed broad potential, including antimicrobial compounds, antioxidants, antitumor agents, enzymes, and organic acids. We emphasize that accurately identifying and depositing fungal isolates in reference collections are crucial for reliable research and effective industrial applications, driving metabolic bioactivity and the production of substances with the potential to inhibit pathogens. Conserving and protecting the cave environment is imperative, considering its continuous potential for discovery and contribution to scientific advancement.

Indexed as

biotechnological applicationsfungafungal biotechnologyfungal metabolitesspeleomycology

Identifiers

PMID39997439
PMCPMC11856267

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.