Evidence map›Paper›PMID 39997646›Full record

ReviewNeurology international2025

fMRI Insights into Visual Cortex Dysfunction as a Biomarker for Migraine with Aura.

Damian Pikor, Natalia Banaszek-Hurla, Alicja Drelichowska, Mikołaj Hurla, Jolanta Dorszewska, Tomasz Wolak, Wojciech Kozubski

Abstract readReview
In one paragraph

Review in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Damian PikorLaboratory of Neurobiology, Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0009-0009-1789-9925
Natalia Banaszek-HurlaLaboratory of Neurobiology, Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.
Alicja DrelichowskaLaboratory of Neurobiology, Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0009-0000-6901-9269
Mikołaj HurlaLaboratory of Neurobiology, Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.
Jolanta DorszewskaLaboratory of Neurobiology, Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.ORCID 0000-0002-8241-0403
Tomasz WolakWorld Hearing Center, Bioimaging Research Center of Institute of Physiology and Pathology of Hearing, 05-830 Kajetany, Poland.
Wojciech KozubskiChair and Department of Neurology, Poznań University of Medical Sciences, 60-355 Poznan, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine with aura (MwA) is a common and severely disabling neurological disorder, characterised by transient yet recurrent visual disturbances, including scintillating scotomas, flickering photopsias, and complex geometric patterns. These episodic visual phenomena significantly compromise daily functioning, productivity, and overall quality of life. Despite extensive research, the underlying pathophysiological mechanisms remain only partially understood. Cortical spreading depression (CSD), a propagating wave of neuronal and glial depolarisation, has been identified as a central process in MwA. This phenomenon is triggered by ion channel dysfunction, leading to elevated intracellular calcium levels and excessive glutamate release, which contribute to widespread cortical hyperexcitability. Genetic studies, particularly involving the

Indexed as

cortical hyperexcitabilityfunctional magnetic resonance imaging (fMRI)migraine with aura (MwA)neuroimaging biomarkersvisual cortex dysfunction

Identifiers

PMID39997646
PMCPMC11858725

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.