Evidence map›Paper›PMID 39998064›Full record

ArticleToxins2025

Release of Hypoglycin A from Hypoglycin B and Decrease of Hypoglycin A and Methylene Cyclopropyl Glycine Concentrations in Ruminal Fluid Batch Cultures.

Anna Maria Engel, Ahmed H El-Khatib, Martin Bachmann, Monika Wensch-Dorendorf, Fenja Klevenhusen, Stefan Weigel, Robert Pieper, Annette Zeyner

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna Maria EngelGerman Federal Institute for Risk Assessment, 10589 Berlin, Germany.
Ahmed H El-KhatibGerman Federal Institute for Risk Assessment, 10589 Berlin, Germany.ORCID 0000-0002-2012-5893
Martin BachmannGerman Federal Institute for Risk Assessment, 10589 Berlin, Germany.ORCID 0000-0002-1264-997X
Monika Wensch-DorendorfInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0003-1634-0918
Fenja KlevenhusenFaculty of Organic Agriculture, University of Kassel, 37213 Witzenhausen, Germany.ORCID 0000-0001-6015-5459
Stefan WeigelGerman Federal Institute for Risk Assessment, 10589 Berlin, Germany.ORCID 0000-0002-4197-5758
Robert PieperGerman Federal Institute for Risk Assessment, 10589 Berlin, Germany.
Annette ZeynerInstitute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, 06120 Halle (Saale), Germany.ORCID 0000-0001-5901-1394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transformation of hypoglycin A (HGA), hypoglycin B (HGB), and methylene cyclopropyl glycine (MCPrG) in ruminal fluid batch cultures was investigated, and the effect of these toxins on the batch culture microorganisms using microbial metabolites was measured. An experiment was conducted using ovine ruminal fluid batch cultures and the ANKOM RF Gas Production System over four runs, each with an incubation period of 48 h. The fermenters contained 200 mg of (i) a substrate mixture (80% cellulose, 20% starch; CSM), (ii) CSM and 1.5 mL of a solution of pure toxins (a mixture of 500 ng/mL HGA and MCPrG each; PCM), or (iii) CSM and 100 mg sycamore maple seeds (SMS). Each fermenter contained 30 mL of inoculum (ruminal fluid and buffer, 1:2

Indexed as

GlycineRumenAnimalsBatch Cell Culture TechniquesFermentationSheepGlycineatypical myopathyphytotoxinsrumen fermentationsecondary plant metabolitessycamore maple tree

Identifiers

PMID39998064
PMCPMC11860860

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.