Evidence map›Paper›PMID 39998310›Full record

ArticleAnnals of the New York Academy of Sciences2025

Age-dependent reduction in voltage-gated inward sodium current and Scn8a gene expression in murine stellate ganglia.

Bonn Lee, Shiraz Ahmad, Charlotte E Edling, Christopher L-H Huang, Fiona E N LeBeau, Kamalan Jeevaratnam

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In one paragraph

Article in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bonn LeeSchool of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Shiraz AhmadSchool of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Charlotte E EdlingSchool of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Christopher L-H HuangPhysiological Laboratory, University of Cambridge, Cambridge, UK.
Fiona E N LeBeauBiosciences Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK.
Kamalan JeevaratnamSchool of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.ORCID 0000-0002-6232-388X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stellate ganglia (SG) provide sympathetic innervation to the heart and may predispose the myocardial conducting system to arrhythmias. However, little is known about age-related changes in the electrophysiology of murine SG. We investigated alterations in the electrophysiological properties of SG with aging. The loose patch clamp technique was adapted to SG tissue to investigate the voltage-gated ionic currents in its neuronal cells. We compared SG and ventricular cells from young (4 months) and aged (13 months) C57BL/6J mice to explore age-related alterations in their voltage-gated ionic currents (n > 30 patches, eight mice in each group). We observed that the voltage-gated inward sodium current (peak I

Indexed as

AgingSodium ChannelsStellate GanglionAnimalsMiceMice, Inbred C57BLNAV1.6 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium ChannelPatch-Clamp TechniquesNAV1.6 Voltage-Gated Sodium ChannelNAV1.8 Voltage-Gated Sodium ChannelScn8a protein, mouseSodium Channelsagingloose patch clampNav 1.6 channelScn8astellate ganglia

Identifiers

PMID39998310
PMCPMC11918529

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.