Evidence map›Paper›PMID 39999013›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2025

Steatotic Liver Disease in Younger Adults is Associated With Altered Gut Microbiology.

Yasmina Tashkent, Jocelyn M Choo, Alyson Richard, Zhengyi Wang, Luis Calzadilla-Bertot, Egi Vasil, Sophie Miller, Steven L Taylor, Kerry L Ivey, Richard Woodman and 9 more

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Article in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yasmina TashkentMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.ORCID 0000-0001-5404-551X
Jocelyn M ChooMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Alyson RichardMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Zhengyi WangMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-1738-2207
Luis Calzadilla-BertotMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0001-9221-0272
Egi VasilMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Sophie MillerMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Steven L TaylorMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Kerry L IveyDivision of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Richard WoodmanFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Brendan AdlerEnvision Medical Imaging, Wembley, Western Australia, Australia.
Oyekoya T AyonrindeMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-0598-151X
John K OlynykMedical School, Curtin University, Bentley, Western Australia, Australia.ORCID 0000-0003-0417-3411
Lawrence J BeilinMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-4853-7360
Trevor A MoriMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Alan J WiggFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Kate R MullerFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Leon A AdamsMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-3968-7909
Geraint B RogersMicrobiome and Host Health Program, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Funding

Gastroenterological Society of Australia
6 · The paper itself

Abstract

BACKGROUND AND

aimsSteatotic liver disease (SLD) is a leading cause of chronic liver disease worldwide. As SLD pathogenesis has been linked to gut microbiome alterations, we aimed to identify SLD-associated gut microbiome features early in SLD development by utilising a highly characterised cohort of community-dwelling younger adults. METHODS AND

resultsAt age 27 years, 588 participants of the Raine Study Generation 2 underwent cross-sectional assessment. Hepatic steatosis was quantified using a validated magnetic resonance imaging (MRI) volumetric liver fat fraction (VLFF) equation (HepaFat). Of the 588 participants, 488 (83%) were classified as having 'no SLD' (VLFF ≤ 3.55%), 76 (12.9%) with 'mild-moderate' SLD (VLFF: 3.56%-13.4%) and 24 (4.10%) with 'severe' SLD (VLFF > 13.4%). Stool microbiome profiling identified an association between severe SLD and lower microbiota alpha diversity (observed features [p = 0.015], Pielou evenness [p = 0.001] and Shannon diversity [p = 0.002]) compared to no SLD. Faecal microbiota composition differed significantly between no SLD and both mild-moderate (p = 0.004) and severe SLD groups (p = 0.001). There was no significant difference in microbiota dispersion between SLD groups. Reduced relative abundance of short-chain fatty acid producing bacteria, and higher levels of proinflammatory bacterial taxa, were both significantly associated with severe SLD (q < 0.05).

conclusionsSLD in younger adults is associated with reduced intestinal microbial diversity and a pattern of bacterial taxa depletion that is consistent with other chronic inflammatory conditions. Our characterisation of gut microbiome characteristics in early SLD development provides a potential basis for risk identification and reduction.

trial registrationThe Raine Study is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617001599369).

Indexed as

Fatty LiverGastrointestinal MicrobiomeAdultCross-Sectional StudiesFecesFemaleHumansLiverMagnetic Resonance ImagingMalefatty livergastrointestinal microbiomemicrobiota

Identifiers

PMID39999013
PMCPMC11855901

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.