Evidence map›Paper›PMID 39999609›Full record

ArticleBiosensors & bioelectronics2025

A nanoplasmonic cell-on-a-chip for in situ monitoring of PD-L1

Chuanyu Wang, Lang Zhou, Xuejia Kang, Chung-Hui Huang, Zhuangqiang Gao, Jialiang Shen, Shuai Wu, Siqi Wu, Yuxin Cai, Weiqiang Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chuanyu WangMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Lang ZhouMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Xuejia KangMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849; Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Chung-Hui HuangDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Zhuangqiang GaoMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Jialiang ShenMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Shuai WuMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Siqi WuMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Yuxin CaiMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Weiqiang ChenDepartment of Mechanical and Aerospace Engineering, New York University, Brooklyn, NY, 11201, USA; Department of Biomedical Engineering, New York University, Brooklyn, NY, 11201, USA.
Siyuan DaiMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849.
Pengyu ChenMaterials Engineering, Department of Mechanical Engineering, Auburn University, Auburn, AL, USA, 36849. Electronic address: pengyuc@auburn.edu.

Funding

Purchase of a modularized confocal microscopeR35GM133795 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Pengyu Chen · 2019 to 2026
$3.3M
Purchase of spinning disk confocal microscopeR35GM133646 · NIGMS · NEW YORK UNIVERSITY · PI CHEN, WEIQIANG · 2019 to 2023
$2.0M
NIGMS NIH HHS R35 GM133646NIGMS NIH HHS R35 GM133795
6 · The paper itself

Abstract

Despite the transformative impact of immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway in cancer therapy, up to 80% of patients fail to respond, necessitating reliable predictive biomarkers to guide treatment decisions. Recent studies highlight the critical role of tumor-derived exosomal PD-L1 in immune evasion, and its potential as a diagnostic and prognostic biomarker in cancer immunotherapy. However, significant challenges remain in elucidating the functional roles of PD-L1

Indexed as

B7-H1 AntigenBiosensing TechniquesExosomesLab-On-A-Chip DevicesNeoplasmsCell Line, TumorHumansImmunoassayT-LymphocytesB7-H1 AntigenCD274 protein, human

Identifiers

PMID39999609
PMCPMC11996229

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.