Evidence map›Paper›PMID 39999877›Full record

ArticleOpen biology2025

PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in

Anna Frappaolo, Gianluca Zaccagnini, Maria Giovanna Riparbelli, Gianni Colotti, Giuliano Callaini, Maria Grazia Giansanti

Abstract read
In one paragraph

Article in Open biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. International journal of molecular sciences · 2025
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna FrappaoloIstituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Piazzale A. Moro 5, 00185, Roma, Italy.
Gianluca ZaccagniniIstituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Piazzale A. Moro 5, 00185, Roma, Italy.
Maria Giovanna RiparbelliDipartimento di Scienze della Vita, Università di Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Gianni ColottiIstituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Scienze Biochimiche 'A. Rossi-Fanelli', Università Sapienza di Roma, Piazzale A. Moro 5, 00185, Roma, Italy.
Giuliano CallainiDipartimento di Scienze della Vita, Università di Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Maria Grazia GiansantiIstituto di Biologia e Patologia Molecolari del CNR, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Piazzale A. Moro 5, 00185, Roma, Italy.ORCID 0000-0002-6753-7262

Funding

Associazione Italiana per la Ricerca sul CancroMinistero dell'Università e della Ricerca
6 · The paper itself

Abstract

The PACS (phosphofurin acidic cluster sorting protein) proteins are membrane trafficking regulators, required for maintaining cellular homeostasis and preventing disease states. Mutations in human

Indexed as

CytokinesisDrosophila melanogasterDrosophila ProteinsGolgi ApparatusSeizuresVesicular Transport ProteinsAnimalsDisease Models, AnimalHumansMalePhenotypeDrosophila ProteinsVesicular Transport ProteinscytokinesisDrosophilamembrane traffickingmodel organismneurodevelopmental diseasePACS

Identifiers

PMID39999877
PMCPMC11858789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.