Evidence map›Paper›PMID 40000226›Full record

ReviewAnalytical chemistry2025

Recent Advances in Mass Spectrometry-Based Bottom-Up Proteomics.

Cameron S Movassaghi, Jie Sun, Yuming Jiang, Natalie Turner, Vincent Chang, Nara Chung, Ryan J Chen, Elizabeth N Browne, Chuwei Lin, Devin K Schweppe and 2 more

Abstract readReview
In one paragraph

Review in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Site-specific O-glycans influence lacritin structure and multimerization in tears.Protein science : a publication of the Protein Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cameron S MovassaghiDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, California 90048, United States.
Jie SunDepartment of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee 37996, United States.
Yuming JiangDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, California 90048, United States.
Natalie TurnerDepartments of Molecular Medicine and Neurobiology, Scripps Research Institute, La Jolla, California 92037, United States.ORCID 0000-0002-2641-2295
Vincent ChangDepartment of Chemistry, Yale University, 275 Prospect Street, New Haven, Connecticut 06511, United States.
Nara ChungDepartment of Chemistry, Yale University, 275 Prospect Street, New Haven, Connecticut 06511, United States.
Ryan J ChenDepartment of Chemistry, Yale University, 275 Prospect Street, New Haven, Connecticut 06511, United States.
Elizabeth N BrowneDepartment of Chemistry, Yale University, 275 Prospect Street, New Haven, Connecticut 06511, United States.
Chuwei LinDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0000-0002-8640-5695
Devin K SchweppeDepartment of Genome Sciences, University of Washington, Seattle, Washington 98105, United States.ORCID 0000-0002-3241-6276
Stacy A MalakerDepartment of Chemistry, Yale University, 275 Prospect Street, New Haven, Connecticut 06511, United States.ORCID 0000-0003-2382-5067
Jesse G MeyerDepartment of Computational Biomedicine, Cedars Sinai Medical Center, Los Angeles, California 90048, United States.ORCID 0000-0003-2753-3926

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Democratizing Multi-Omics to Expedite Discovery of Hidden Metabolic PathwaysR35GM142502 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI MEYER, JESSE · 2021 to 2025
$2.2M
Predoctoral Training at the Interface Chemistry and BiologyT32GM149444 · NIGMS · YALE UNIVERSITY · PI Jason Michael Crawford · 2023 to 2026
$2.2M
Technology for evaluating drug-binding responses to small-molecule perturbationR35GM150919 · NIGMS · UNIVERSITY OF WASHINGTON · PI Devin Karl Schweppe · 2023 to 2026
$1.6M
NIAAA NIH HHS T32 AA007456NIGMS NIH HHS R35 GM142502NIGMS NIH HHS R35 GM150919NIGMS NIH HHS T32 GM149444
6 · The paper itself

Abstract

Mass spectrometry-based proteomics is about 35 years old, and recent progress appears to be speeding up across all subfields. In this review, we focus on advances over the last two years in select areas within bottom-up proteomics, including approaches to high-throughput experiments, data analysis using machine learning, drug discovery, glycoproteomics, extracellular vesicle proteomics, and structural proteomics.

Indexed as

Mass SpectrometryProteomicsDrug DiscoveryExtracellular VesiclesHumansMachine Learning

Identifiers

PMID40000226
PMCPMC12117541

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.