ArticleBMC pregnancy and childbirth2025
Universal screening for hyperglycemia in early pregnancy and the risk of adverse pregnancy outcomes.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Independent and synergistic effects of OGTT-based hyperglycemia phenotypes and gestational weight gain on feto-maternal outcomes in GDM.BMC pregnancy and childbirth · 2026Article
- Effectiveness of a lifestyle intervention for pregnant women with abnormal glucose metabolism in early pregnancy (EAGM): protocol for a multicentre, open-labelled, two-arm, pragmatic randomised controlled trial.BMC pregnancy and childbirth · 2026Article
- Assessment of the Burden of Maternal Hypertensive Disorders and the Quality of Care in China: A Systematic Analysis of the Global Burden of Disease (GBD) 2021 Study.International journal of women's health · 2026Article
- 15. Management of Diabetes in Pregnancy: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- 2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- miR-326 serves as a diagnostic biomarker in gestational diabetes mellitus and its regulatory effect on trophoblast cell viability.Irish journal of medical science · 2025Article
- Transcription Factor EB (TFEB) Expression and Localization in the Third-Trimester Placenta.International journal of molecular sciences · 2025Article
- MV-Flow imaging for evaluating the placental function of gestational diabetes mellitus.Frontiers in endocrinology · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThis study aimed to evaluate the screening outcomes in women with hyperglycemia in early pregnancy (fasting plasma glucose [FPG] 5.1-6.9 mmol/L and/or HbA1c 39-46 mmol/mol before 20 weeks of gestation).
methodsThis multicenter retrospective cohort study was conducted in China between 2016 and 2022. In our setting, all women without pregestational diabetes performed both FPG and HbA1c screening at the first prenatal visit. Logistic regression models adjusted for confounders were performed to assess the associations of hyperglycemia in early pregnancy with adverse pregnancy outcomes. Subgroup analyses were explored according to the subsequent diagnosis of gestational diabetes (GDM, with or without).
resultsOf the 42,999 women in the analysis, 2515 (5.8%) women had hyperglycemia in early pregnancy. Compared with women with normal FPG and HbA1c levels, women with FPG 5.1-6.9 mmol/L and/or HbA1c 39-46 mmol/mol had a 3-fold increased risk of GDM (aOR 3.85; 95% CI 3.52-4.20), and 1-fold higher risk of hypertensive disorders of pregnancy (1.42; 1.20-1.67), shoulder dystocia (1.30; 1.11-1.52), preterm birth (1.30; 1.11-1.52), large-for-gestational-age (1.26; 1.12-1.43), and macrosomia (1.43; 1.19-1.73). Women with hyperglycemia in early pregnancy complicated by GDM were associated with a 50%, 84%, 48% and 24% increase in the odds of developing hypertensive disorders of pregnancy (1.50; 1.21-1.84), preterm premature rupture of membranes (1.84; 1.09-3.10), preterm birth (1.48; 1.22-1.81) and large-for-gestational-age (1.24; 1.05-1.45), respectively, compared with those without hyperglycemia.
conclusionsPregnant women with hyperglycemia in early pregnancy have an increased risk of adverse pregnancy outcomes, and women with these conditions complicated by GDM are at higher risk than those without. Further research is needed to explore whether the incidence of GDM can be reduced by early intervention and therefore prevent the relevant adverse pregnancy outcomes.
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