Evidence map›Paper›PMID 40001477›Full record

ArticleBiomolecules2025

Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.

Shaw-Min Hou, Chun-Ming Yang, Wei-Chieh Huang, Ssu-Wei Cheng, Ting-Lin Yen, Chih-Wei Hsia, Cheng-Ying Hsieh, Chih-Hsuan Hsia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Chemical profiling ofFrontiers in veterinary science · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaw-Min HouGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chun-Ming YangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wei-Chieh HuangGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Ssu-Wei ChengDepartment of Pharmacy, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.ORCID 0000-0002-9156-0665
Ting-Lin YenDepartment of Medical Research, Cathay General Hospital, Taipei 106, Taiwan.ORCID 0000-0002-1454-0521
Chih-Wei HsiaDepartment of Medical Research, Taipei Medical University Hospital, Taipei 110, Taiwan.ORCID 0000-0002-4508-6181
Cheng-Ying HsiehDepartment of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chih-Hsuan HsiaGraduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Funding

Cathay General Hospital CGH-MR-A11226Chi Mei Medical Center-Taipei Medical University 110CM-TMU-18National Science and Technology Council, Taiwan MOST 110-2320-B341-001-MY3National Science and Technology Council, Taiwan NSTC 113-2320-B341-002-MY3Shin Kong Wu Ho-Su Memorial Hospital 2023SKHAND006Shin Kong Wu Ho-Su Memorial Hospital 2024SKHAND008
6 · The paper itself

Abstract

Inflammation, a fundamental response to infection and injury, involves interactions among immune cells and signaling molecules. Dysregulated inflammation contributes to diseases such as autoimmune disorders and cancer. Interleukin-1 beta (IL-1β), produced by macrophages in response to lipoteichoic acid (LTA) from Gram-positive bacteria, is a key inflammatory mediator. Glabridin (GBD), a bioactive compound from licorice root, exhibits anti-inflammatory properties. This study investigates GBD's effects on LTA-induced proinflammatory signaling in RAW 264.7 murine macrophages and alveolar macrophages, MH-S, focusing on

Indexed as

Interleukin-1betaIsoflavonesLipopolysaccharidesMacrophage ActivationMacrophages, AlveolarMacrophages, PeritonealNitric Oxide Synthase Type IIPhenolsTeichoic AcidsAnimalsMAP Kinase Signaling SystemMiceNitric OxideRAW 264.7 CellsSignal TransductionglabridinIL1B protein, mouseInterleukin-1betaIsoflavonesLipopolysaccharideslipoteichoic acidNitric OxideNitric Oxide Synthase Type IINos2 protein, mousePhenolsTeichoic AcidsglabridinIL-1βiNOSlipoteichoic acidmacrophagesMAPK pathwayNF-κB

Identifiers

PMID40001477
PMCPMC11853366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.