CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease.

Menglong Zhao, Mingzheng Han, Shuaihao Guo, Zhaoxin Tang

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

N-acetylcysteine reduces the hepatic complications of social isolation stress through modulation of interleukin 1 and 6 gene expression and liver enzymes in mice.Scientific reports · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Menglong ZhaoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Mingzheng HanCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Shuaihao GuoCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Zhaoxin TangCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Funding

National Natural Science Foundation of China No. 31572585

6 · The paper itself

Abstract

The etiology of type 1 diabetes mellitus (T1DM) is intricate, leading to its classification as an autoimmune metabolic disorder. T1DM often coexists with various visceral diseases. N-acetylcysteine (NAC) is widely acknowledged for its potent antioxidant properties. Studies have demonstrated that the combination of NAC and insulin can effectively alleviate iron-induced nephropathy in T1DM and mitigate oxidative stress injury in skeletal muscle associated with the condition. However, the potential impact of NAC alone on liver disease in individuals with T1DM remains uncertain. In this study, a beagle model was established to simulate T1DM, enabling investigation into the role of NAC in liver disease using RNA-seq biogenic analysis and subsequent validation through molecular biological methods. The findings revealed suppressed expression of

Indexed as

AcetylcysteineChemokine CXCL12Diabetes Mellitus, Type 1Liver DiseasesAnimalsDisease Models, AnimalDogsHumansLiverMaleAcetylcysteineChemokine CXCL12CXCL12 protein, humanbeaglesCXCL12NACT1DM liver disease

Identifiers

PMID40001479

DOI10.3390/biom15020176

PMCPMC11853168

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.