Evidence map›Paper›PMID 40001510›Full record

ArticleBiomolecules2025

A Modular Customizable Ligand-Conjugate (LC) System Targeting Ghrelin

Amber L Ford, Caine W Taft, Andrea M Sprague-Getsy, Gracie C Carlson, Nilamber A Mate, Michelle A Sieburg, John D Chisholm, James L Hougland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amber L FordDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0009-0009-6224-7301
Caine W TaftDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Andrea M Sprague-GetsyDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Gracie C CarlsonDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0009-0007-4065-5932
Nilamber A MateDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0002-4441-7188
Michelle A SieburgDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0002-2765-7235
John D ChisholmDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0001-9518-2393
James L HouglandDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.ORCID 0000-0003-0444-1017

Funding

Defining the Molecular Architecture for Transmembrane Acylation by a Membrane Bound O-AcyltransferaseR01GM134102 · NIGMS · SYRACUSE UNIVERSITY · PI CHISHOLM, JOHN DANIEL, HOUGLAND, JAMES · 2019 to 2021
$1.0M
NIGMS NIH HHS R01 GM134102NIH HHS GM134102NSF CHE-1659775
6 · The paper itself

Abstract

Ghrelin is a 28 amino acid peptide hormone that impacts a wide range of biological processes, including appetite regulation, glucose metabolism, growth hormone regulation, and cognitive function. To bind and activate its cognate receptor, ghrelin must be acylated on a serine residue in a post-translational modification performed by ghrelin

Indexed as

AcyltransferasesGhrelinAcylationAnimalsHumansLigandsMaleProstatic NeoplasmsProtein Processing, Post-TranslationalAcyltransferasesGhrelinLigandsMBOAT4 protein, humanghrelinghrelin O-acyltransferaseGHSRmembrane-bound O-acyltransferasemembrane enzymepeptide mimetic inhibitorposttranslational modificationprotein acylation

Identifiers

PMID40001510
PMCPMC11852496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.