A Neuroprotective Peptide Modulates Retinal cAMP Response Element-Binding Protein (CREB), Synapsin I (SYN1), and Growth-Associated Protein 43 (GAP43) in Rats with Silicone Oil-Induced Ocular Hypertension.

Gretchen A Johnson, Raghu R Krishnamoorthy, Ram H Nagaraj, Dorota L Stankowska

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Research Advances in Glanimal Models of Glaucoma: Exploring Multidimensional Mechanisms and Novel Therapeutic Strategies.Pharmaceutics · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gretchen A JohnsonNorth Texas Eye Research Institute, College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.ORCID 0000-0001-7330-269X

Raghu R KrishnamoorthyNorth Texas Eye Research Institute, College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Ram H NagarajDepartment of Ophthalmology, School of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.

Dorota L StankowskaNorth Texas Eye Research Institute, College of Biomedical and Translational Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026

$6.9M

Mechanisms underlying endothelin mediated neurodegeneration in glaucomaR01EY028179 · NEI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI KRISHNAMOORTHY, RAGHU R · 2017 to 2025

$2.9M

NEI NIH HHS R01 EY028179NEI NIH HHS R01EY028179Neurobiology of Aging and Alzheimer's Disease T32AG020494NIA NIH HHS T32 AG020494Research to Prevent Blindness Gates Grubstake Award

6 · The paper itself

Abstract

This study evaluated the neuroprotective potential of peptain-1 conjugated to a cell-penetrating peptide (CPP-P1) in an ocular hypertension model of glaucoma. Brown Norway (BN) rats were subjected to intraocular pressure (IOP) elevation via intracameral injection of silicone oil (SO), with concurrent intravitreal injections of either CPP-P1 or a vehicle. Retinal cross-sections were analyzed for markers of neuroprotection, including cAMP response element-binding protein (CREB), phosphorylated CREB (p-CREB), growth-associated protein-43 (GAP43), synapsin-1 (SYN1), and superoxide dismutase 2 (SOD2). Hematoxylin and eosin staining was used to assess retinal-layer thickness. SO-treated rats exhibited significant reductions in the thickness of the inner nuclear layer (INL, 41%,

Indexed as

Cell-Penetrating PeptidesCyclic AMP Response Element-Binding ProteinGAP-43 ProteinNeuroprotective AgentsOcular HypertensionRetinaSynapsinsAnimalsDisease Models, AnimalIntraocular PressureMaleRatsRats, Inbred BNRetinal Ganglion CellsCell-Penetrating PeptidesCreb1 protein, ratCyclic AMP Response Element-Binding ProteinGAP-43 ProteinNeuroprotective AgentsSynapsinsCPP-P1CREB signalingglaucomaneurodegenerationneuroprotectionpeptain-1αB-crystallin

Identifiers

PMID40001522

DOI10.3390/biom15020219

PMCPMC11852426

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.