Evidence map›Paper›PMID 40002907›Full record

ReviewBiomedicines2025

Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation.

Kawthar Safi, Angelika Joanna Pawlicka, Bhaskar Pradhan, Jan Sobieraj, Andriy Zhylko, Marta Struga, Michał Grąt, Alicja Chrzanowska

Abstract readReview
In one paragraph

Review in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kawthar SafiDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-1325-7094
Angelika Joanna PawlickaDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0009-0003-0751-2818
Bhaskar PradhanDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0003-2751-1428
Jan Sobieraj1st Chair and Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0009-0009-0008-9176
Andriy ZhylkoDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.ORCID 0000-0001-7851-7147
Marta StrugaDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-0181-3607
Michał GrątDepartment of General, Transplant and Liver Surgery, Medical University of Warsaw, Banacha 1A, 02-097 Warsaw, Poland.
Alicja ChrzanowskaDepartment of Biochemistry, Medical University of Warsaw, 02-097 Warsaw, Poland.ORCID 0000-0002-6928-4561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplantation is a critical and evolving field in modern medicine, offering life-saving treatment for patients with end-stage liver disease and other hepatic conditions. Despite its transformative potential, transplantation faces persistent challenges, including a global organ shortage, increasing liver disease prevalence, and significant waitlist mortality rates. Current donor evaluation practices often discard potentially viable livers, underscoring the need for refined graft assessment tools. This review explores advancements in graft evaluation and utilization aimed at expanding the donor pool and optimizing outcomes. Emerging technologies, such as imaging techniques, dynamic functional tests, and biomarkers, are increasingly critical for donor assessment, especially for marginal grafts. Machine learning and artificial intelligence, exemplified by tools like LiverColor, promise to revolutionize donor-recipient matching and liver viability predictions, while bioengineered liver grafts offer a future solution to the organ shortage. Advances in perfusion techniques are improving graft preservation and function, particularly for donation after circulatory death (DCD) grafts. While challenges remain-such as graft rejection, ischemia-reperfusion injury, and recurrence of liver disease-technological and procedural advancements are driving significant improvements in graft allocation, preservation, and post-transplant outcomes. This review highlights the transformative potential of integrating modern technologies and multidisciplinary approaches to expand the donor pool and improve equity and survival rates in liver transplantation.

Indexed as

controlled attenuation parameter (CAP)deceased donor liver transplantation (DDLT)donors after brain death (DBD)donors after circulatory death (DCD)hepatic steatosis (HS)liver stiffness (LS)living donor liver transplantation (LDLT)marginal donorstransient elastography (TE)

Identifiers

PMID40002907
PMCPMC11852418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.