Discovery of Isobavachin, a Natural Flavonoid, as an Apolipoprotein E4 (ApoE4) Structure Corrector for Alzheimer's Disease.

Sachin P Patil, Bella R Kuehn, Christina McCullough, Dean Bates, Hadil Hazim, Mamadou Diallo, Naomie Francois

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sachin P PatilNanoBio Laboratory, Widener University, Chester, PA 19013, USA.ORCID 0000-0002-1354-0386

Bella R KuehnNanoBio Laboratory, Widener University, Chester, PA 19013, USA.

Christina McCulloughNanoBio Laboratory, Widener University, Chester, PA 19013, USA.ORCID 0009-0005-3428-6144

Dean BatesNanoBio Laboratory, Widener University, Chester, PA 19013, USA.

Hadil HazimNanoBio Laboratory, Widener University, Chester, PA 19013, USA.

Mamadou DialloNanoBio Laboratory, Widener University, Chester, PA 19013, USA.

Naomie FrancoisNanoBio Laboratory, Widener University, Chester, PA 19013, USA.

Funding

Alzheimer's Association NIRP-12-258855

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by extensive neurodegeneration and consequent severe memory loss. Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for AD, with its pathological effects linked to structural instability and altered interactions with lipids and other important disease proteins including amyloid beta (Aβ) and tau (

Indexed as

Alzheimer DiseaseApolipoprotein E4FlavonoidsDrug DiscoveryHumansApolipoprotein E4FlavonoidsAlzheimer’s diseaseApolipoprotein E4 (ApoE4)bioavailable compoundsflavonoidsIsobavachinmolecular dockingmolecular dynamicsprotein stabilizationstructure correctors

Identifiers

PMID40005250

DOI10.3390/molecules30040940

PMCPMC11858207

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.