Evidence map›Paper›PMID 40006571›Full record

ReviewPharmaceutics2025

Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview.

Álisson E F Alves, Anne B C Barros, Lindomara C F Silva, Lucas M M Carvalho, Graziela M A Pereira, Ana F C Uchôa, José M Barbosa-Filho, Marcelo S Silva, Karla P O Luna, Karla S R Soares and 1 more

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Álisson E F AlvesLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Anne B C BarrosLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Lindomara C F SilvaLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Lucas M M CarvalhoLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.ORCID 0009-0002-5570-6046
Graziela M A PereiraLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Ana F C UchôaLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-6872-082X
José M Barbosa-FilhoPost-Graduated Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-9567-4096
Marcelo S SilvaPost-Graduated Program in Natural and Synthetic Bioactive Products, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Karla P O LunaVenomics Laboratory (LabVenom), Center for Biological and Health Sciences, State University of Paraíba (UEPB), Campus I, Bodocongó, Campina Grande 58429-600, PB, Brazil.
Karla S R SoaresLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.
Francisco H Xavier-JúniorLaboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Paraíba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-8238-3380

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins. The vast diversity of snake species and their venom complexities underline the need for ongoing research. This review is dedicated to exploring the integration of snake venom with nanoparticles to enable their use in human therapies aiming to develop treatments. The complex mixture of snake venom not only inflicts significant pathological effects but also offers valuable insights for the creation of innovative therapies, particularly in the realm of nanobiotechnology. Nanoscale encapsulation not only mitigates the inherent toxicity of snake venom but also amplifies their antitumoral, antimicrobial, and immunomodulatory properties. The synergy between venom-derived macromolecules and nanotechnology offers a novel pathway for augmenting the efficacy and safety of conventional antivenom therapies, extending their applicability beyond treating bites to potentially addressing a myriad of health issues. In conclusion, nanotechnology presents a compelling therapeutic frontier that promises to improve current treatment modalities and ameliorate the adverse effects associated with venomous snakebites.

Indexed as

drug deliverydrug discoverynanoformulationnanomedicinevenom peptides

Identifiers

PMID40006571
PMCPMC11858983

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.