Evidence map›Paper›PMID 40006902›Full record

ArticleViruses2025

Chronic Systemic SARS-CoV-2 Infection Without Respiratory Involvement in an Immunocompromised Patient.

Francisco Tejerina, Daniel Peñas-Utrilla, Marta Herranz, Pilar Catalán, Mercedes Marín, Lara Mesones, José Manuel García-Domínguez, Beatriz Merino, Leire Pérez, Chiara Fanciulli and 7 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Francisco TejerinaClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-4136-3575
Daniel Peñas-UtrillaClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-4454-4638
Marta HerranzClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Pilar CatalánClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Mercedes MarínClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0001-8639-5215
Lara MesonesClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-9453-0656
José Manuel García-DomínguezDepartment of Neurology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-5205-3652
Beatriz MerinoGastroenterology Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Leire PérezClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Chiara FanciulliClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0003-2175-9027
Patricia MuñozClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0001-5706-5583
Carmen Rodríguez-GonzalezPharmacy Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Cristina DiezClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-3508-9979
Teresa AldámizClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0002-4374-6940
Andrea Molero-SalinasClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.
Laura Pérez-LagoInstituto de Investigación Sanitaria Gregorio Marañón, 28009 Madrid, Spain.ORCID 0000-0001-5249-7619
Darío García de ViedmaClinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón, 28007 Madrid, Spain.ORCID 0000-0003-3647-7110

Funding

Fundación Mutua Madrileña Project FMM22/01
6 · The paper itself

Abstract

In a patient on immunosuppressant treatment, SARS-CoV-2 RNA was documented in different extra-respiratory samples over several months in the absence of positive determinations in upper respiratory samples. Whole-genome sequencing of these samples showed the acquisition of different single-nucleotide polymorphisms over time, suggesting viral evolution and thus viral viability.

Indexed as

COVID-19Immunocompromised HostSARS-CoV-2Chronic DiseaseFemaleGenome, ViralHumansImmunosuppressive AgentsMaleMiddle AgedPolymorphism, Single NucleotideRNA, ViralWhole Genome SequencingImmunosuppressive AgentsRNA, Viralimmunocompromisedpersistent COVID-19systemic infection

Identifiers

PMID40006902
PMCPMC11860550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.