Evidence map›Paper›PMID 40006921›Full record

ArticleViruses2025

DDX21 Promotes PCV3 Replication by Binding to Cap Protein and Inhibiting Interferon Responses.

Haoyu Sun, Qianhong Dai, Beiyi Zhou, Xiaoyuan Lan, Yonghui Qiu, Qianqian Zhang, Dedong Wang, Yongqiu Cui, Jinshuo Guo, Lei Hou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Haoyu SunCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Qianhong DaiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Beiyi ZhouCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Xiaoyuan LanCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yonghui QiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Qianqian ZhangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Dedong WangCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Yongqiu CuiCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0003-3459-7047
Jinshuo GuoCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Lei HouCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jue LiuCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
Jianwei ZhouCollege of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Funding

the National Key Research and Development Program of China 2022YFD1800300the Natural Science Foundation of Jiangsu Province BK20210807
6 · The paper itself

Abstract

Porcine circovirus type 3 (PCV3) is an emerging pathogen that causes porcine dermatitis, nephropathy syndrome-like symptoms, multisystemic inflammation, and reproductive failure. The PCV3 capsid (Cap) protein interacts with DDX21, which functions mainly through controlling interferon (IFN)-β levels. However, how the interaction between DDX21 and PCV3 Cap regulates viral replication remains unknown. In the present study, upon shRNA-mediated

Indexed as

Capsid ProteinsCircovirusDEAD-box RNA HelicasesInterferon-betaInterferonsVirus ReplicationAnimalsCell LineCircoviridae InfectionsHost-Pathogen InteractionsProtein BindingSwineCapsid ProteinsDEAD-box RNA HelicasesInterferon-betaInterferonscapsid proteinDEAD-box RNA helicase 21porcine circovirus type 3viral replication

Identifiers

PMID40006921
PMCPMC11861039

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.