Evidence map›Paper›PMID 40007355›Full record

ArticleJournal of photochemistry and photobiology. B, Biology2025

Photodynamic priming with red light triggers adaptive immune responses in a pancreatic cancer mouse model.

Pushpamali De Silva, Mohammad A Saad, Joseph W R Swain, Zhiming Mai, Madeline D Kidd, Joanna J Choe, Assiris P Camargo, Sanjay Anand, Vinay Chandrasekhara, Brian W Pogue and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of photochemistry and photobiology. B, Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Palladium(II)-ComplexedACS omega · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pushpamali De SilvaWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Mohammad A SaadWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Joseph W R SwainWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Zhiming MaiWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA.
Madeline D KiddWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Harvard University, Cambridge, MA, USA.
Joanna J ChoeWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Boston College, Chestnut Hill, MA, USA.
Assiris P CamargoWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Bunker Hill Community College, Boston, MA, USA.
Sanjay AnandDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Vinay ChandrasekharaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Kenneth K WangDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
Bryan Q SpringDepartment of Physics, College of Science, Northeastern University, Boston, USA.
Edward V MaytinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Tayyaba HasanWellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA; Division of Health Sciences and Technology, Harvard University and Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address: thasan@mgh.harvard.edu.

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor LiposomeR01CA260340 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HUANG, HUANG CHIAO · 2021 to 2025
$3.2M
Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapyR01CA231606 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA · 2019 to 2025
$3.1M
NCI NIH HHS P01 CA084203NCI NIH HHS R01 CA231606NCI NIH HHS R01 CA260340
6 · The paper itself

Abstract

The poor response of pancreatic ductal adenocarcinoma (PDAC) to treatment, including immunotherapy, is attributed to its tumor microenvironment (TME). An ongoing challenge is the desmoplastic and immunosuppressed TME that evades immune surveillance. Here, we investigate transient modulation of the TME to overcome immunosuppression using a light-activated process, termed photodynamic priming (PDP). As a first step, this study captures the temporal dynamics of variations in immune infiltrates and subsequent immune responses in the TME, spleen, and blood of the KPC mouse model of PDAC post-PDP. In response to PDP, there were transient increases in tumor infiltrating lymphocytes (TIL) in tumors. The TIL population post-PDP includes an enrichment of CD8

Indexed as

Adaptive ImmunityLightPancreatic NeoplasmsPhotochemotherapyAnimalsCarcinoma, Pancreatic DuctalCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorDendritic CellsDisease Models, AnimalLymphocytes, Tumor-InfiltratingMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorRed LightProgrammed Cell Death 1 ReceptorDesmoplasiaImmune checkpoint blockadeImmunogenic cell deathImmunotherapyPhotodynamic therapyTumor-infiltrating lymphocytes

Identifiers

PMID40007355
PMCPMC11895200

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.