Evidence map›Paper›PMID 40010584›Full record

ArticleAmerican heart journal2025

Rationale and design of the women's ischemia syndrome evaluation mechanisms of coronary microvascular dysfunction leading to preheart failure with preserved ejection fraction (WISE Pre-HFPEF).

Tatsunori Takahashi, Janet Wei, Ana C Iribarren, Martha Gulati, Galen Cook-Wiens, Michael D Nelson, Behzad Sharif, Eileen M Handberg, R David Anderson, John Petersen and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03876223 (Women's Ischemia Syndrome Evaluation), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03876223 recruitingnot on this map

Women's Ischemia Syndrome Evaluation (WISE) Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure With Preserved Ejection Fraction (HFpEF)

TypeobservationalSponsorCedars-Sinai Medical CenterRan2019 to 2027Enrolled180ConditionsCoronary Microvascular Dysfunction, Heart Failure With Preserved Ejection Fraction (HFpEF)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tatsunori TakahashiSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Janet WeiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Ana C IribarrenBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Martha GulatiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Galen Cook-WiensBiostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Michael D NelsonBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Behzad SharifKrannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, IN.
Eileen M HandbergDivision of Cardiology, Department of Medicine, University of Florida, Gainesville, FL.
R David AndersonDivision of Cardiology, Department of Medicine, University of Florida, Gainesville, FL.
John PetersenDivision of Cardiology, Department of Medicine, University of Florida, Gainesville, FL.
Daniel S BermanSmidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Carl J PepineDivision of Cardiology, Department of Medicine, University of Florida, Gainesville, FL.
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA. Electronic address: noel.baireymerz@cshs.org.

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
CVD protection mechanisms involving ACE2/Ang-(1-7) axisR01HL056921 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 1996 to 2015
$9.2M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2020 to 2024
$8.7M
Brain Angiotensin In Hypertensive Neurons in CultureR37HL033610 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 2003 to 2012
$5.8M
UFRCC for Cardiovascular Cell Therapy Research NetworkUM1HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2012 to 2018
$4.7M
BRAIN ANGIOTENSIN IN HYPERTENSIVE NEURONS IN CULTURER01HL033610 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K., SUMNERS, COLIN · 1985 to 2017
$4.3M
Women's Ischemia Syndrome EvaluationU01HL064829 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F. · 2001 to 2005
$3.9M
15/24- Healthy Brain and Child Development National ConsortiumU01DA055358 · NIDA · UNIVERSITY OF FLORIDA · PI GURKA, KELLY K., SCOTT, LISA S. · 2021 to 2023
$3.7M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL153500 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2021 to 2025
$3.2M
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
NCATS NIH HHS UL1 TR001427NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL033610NHLBI NIH HHS R01 HL056921NHLBI NIH HHS R01 HL090957NHLBI NIH HHS R01 HL146158NHLBI NIH HHS R01 HL153500NHLBI NIH HHS R37 HL033610NHLBI NIH HHS U01 HL064829NHLBI NIH HHS UM1 HL087366NIA NIH HHS R03 AG032631NIA NIH HHS U54 AG065141NIDA NIH HHS U01 DA055358
6 · The paper itself

Abstract

backgroundThere is increasing recognition that the pathophysiology of coronary microvascular dysfunction (CMD) plays a pivotal role in the development of heart failure with preserved ejection fraction (HFpEF). However, the mechanisms underlying this role are not known. STUDY DESIGN AND

methodsThe Women's Ischemia Syndrome Evaluation Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure With Preserved Ejection Fraction (WISE Pre-HFpEF) is a prospective cohort study enrolling 180 women and men undergoing clinically indicated invasive coronary angiography for suspected ischemia with no obstructive coronary artery disease. The study aims to investigate (1) CMD-related ischemia contribution to myocellular damage and impaired left ventricular (LV) relaxation as determined invasively by ultra-high sensitivity cardiac troponin I (u-hs-cTnI) measurements in the coronary sinus/great cardiac vein and LV pressure-volume loops, respectively, during provocative stress testing with isometric handgrip, and (2) CMD-related ischemic myocellular damage contribution to LV diastolic dysfunction progression as assessed using cardiac magnetic resonance imaging obtained at enrollment and 1-2 years later, along with prospectively repeated ambulatory u-hs-cTnI measurements.

conclusionsThe WISE pre-HFpEF study is designed to investigate whether ischemic myocardial damage secondary to CMD contributes to the progression of LV diastolic dysfunction. The findings from this study will provide new understanding of the role of CMD in HFpEF development as well as the potential benefits of CMD-directed therapies for the prevention and treatment of HFpEF.

trial registrationClilicalTrial.gov, NCT03876223.

Indexed as

Coronary CirculationHeart FailureMyocardial IschemiaStroke VolumeVentricular Dysfunction, LeftAgedCoronary AngiographyFemaleHumansMagnetic Resonance Imaging, CineMaleMicrocirculationMiddle AgedProspective StudiesTroponin ITroponin I

Identifiers

PMID40010584
PMCPMC11952140

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.