Evidence map›Paper›PMID 40010959›Full record

ArticleIn vivo (Athens, Greece)

Renal Expression Levels of C5a Receptor and Autophagy-related Beclin-1 and LC3A/B Are Simultaneously Enhanced Under Immunoglobulin Treatment in a Rat Model of Sepsis.

Özlem Polat, Gunseli Orhun, Ilkay Anakli, Vuslat Yilmaz, Gizem Koral, Canan Ulusoy, Mert Canbaz, Perihan Ergin Ozcan, Erdem Tüzün, Figen Esen

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Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Özlem PolatDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye; ozlemp@yahoo.com.tr.
Gunseli OrhunDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye.
Ilkay AnakliDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye.
Vuslat YilmazDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye.
Gizem KoralDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye.
Canan UlusoyDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye.
Mert CanbazDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye.
Perihan Ergin OzcanDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye.
Erdem TüzünDepartment of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkiye.
Figen EsenDepartment of Anesthesiology and Reanimation, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimSepsis-induced acute kidney injury is a fatal, potentially reversible clinical condition. C5a receptor (C5aR) has been implied to play pivotal roles in both autophagy and sepsis-induced organ dysfunction. The aim of this study was to demonstrate the effects of intravenous immunoglobulin preparations on the expression of autophagy markers and investigate possible association between C5aR expression and autophagy in the kidney tissue of septic rats. MATERIALS AND

methodsSepsis was induced by cecal ligation perforation (CLP) in rats, which were divided into control, sham, CLP+saline, CLP+IgG (250 mg/kg,

resultsCLP did not enhance the renal expression of autophagy markers or C5aR. Contrariwise, IgG, and IgGAM administration reduced mortality caused by the CLP procedure and significantly increased C5aR, beclin-1, and LC3A/B expression levels in kidney samples of septic rats. Surviving rats had higher renal expression levels of C5aR, beclin-1, and LC3A/B than deceased rats. Expression levels of C5aR, beclin-1, and LC3A/B showed a strong correlation during the early stage of CLP-induced sepsis but not in the late stage.

conclusionHuman-derived immunoglobulin preparations may ameliorate sepsis-related organ dysfunction partially through autophagy-related mechanisms. In the early stage of treatment, enhancement of autophagy in the kidney appears to be associated with C5aR expression.

Indexed as

AutophagyBeclin-1KidneyMicrotubule-Associated ProteinsReceptor, Anaphylatoxin C5aSepsisAcute Kidney InjuryAnimalsBiomarkersDisease Models, AnimalGene Expression RegulationMaleRatsAnxa3 protein, ratBeclin-1Becn1 protein, ratBiomarkersMicrotubule-Associated ProteinsReceptor, Anaphylatoxin C5aautophagyIVIgkidneySepsis

Identifiers

PMID40010959
PMCPMC11884498

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.