Evidence map›Paper›PMID 40011615›Full record

ArticleScientific reports2025

Pentraxin3 exacerbates acute pancreatitis injury by inhibiting oxidative phosphorylation pathway.

Wenyue Wang, Yaning Wang, Chenchen Yuan, Fei Cao, Weisong Tang, Qingtian Zhu, Xiaowu Dong, Lihui Deng, Guotao Lu, Qing Xia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenyue Wang *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Yaning Wang *Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Chenchen YuanPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Fei CaoPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Weisong TangPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Qingtian ZhuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Xiaowu DongPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Lihui DengWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Guotao LuPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
Qing XiaWest China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Weiwei ChenPancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, Institute of Digestive Diseases, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China. cww1984@126.com.

Funding

333 High-Level Talents Training Project of Jiangsu Province and Six Talent Peaks Project of Jiangsu Province WSN-11325the National Natural Science Foundation 82004291
6 · The paper itself

Abstract

Local pancreatic necrosis and systemic inflammatory response caused by acute pancreatitis (AP) are closely related to the disease prognosis and severity. This study aimed to explore whether pentraxin 3 (PTX3) regulates AP pancreatic necrosis and reveals the underlying mechanism. By using AP time gradient transcriptomics, proteomics and liquid phase chip analysis, we found a close association between PTX3 and AP. Subsequently, caerulein (CAE) induced in vivo AP model and CCK induced in vitro acinar cell damage model were constructed to determine the expression of PTX3 and its regulation of AP. The results showed that PTX3 was highly expressed in the CAE-induced AP model. And more severe pancreatic tissue damage and increased serum amylase were observed after the intervention of recombinant protein PTX3, which was strongly linked to the decreasing in mitochondrial membrane potential, increasing in reactive oxygen species, and regulation by oxidative phosphorylation pathway. PTX3 could exacerbate acinar cell damage in AP by mediating the process of oxidative phosphorylation.

Indexed as

C-Reactive ProteinOxidative PhosphorylationPancreatitisSerum Amyloid P-ComponentAcinar CellsAnimalsCeruletideDisease Models, AnimalHumansMaleMembrane Potential, MitochondrialMicePentraxinsReactive Oxygen SpeciesSignal TransductionCeruletideC-Reactive ProteinPentraxinsReactive Oxygen SpeciesSerum Amyloid P-ComponentAcinar cell injuryAcute pancreatitisOxidative phosphorylationPentraxin 3Reactive oxygen species

Identifiers

PMID40011615
PMCPMC11865528

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.