Evidence map›Paper›PMID 40011702›Full record

ArticleScientific reports2025

Immune dysregulation in COVID-19 induced ARDS in kidney transplant recipients revealed by single-cell RNA sequencing.

Jielong Pang, Jingyu Huang, Jianing Yu, Binbin Li, Shanshan Wei, Weiluan Cen, Yixuan Xuan, Junzhi Yang, Yongbing Yu, Jingjia Mo and 3 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jielong Pang *Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Jingyu Huang *Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Jianing Yu *Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Binbin LiDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Shanshan WeiDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Weiluan CenDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Yixuan XuanDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Junzhi YangDepartment of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Yongbing YuDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Jingjia MoDepartment of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China.
Junyu LuGuangxi Health Commission key Laboratory of Emergency and Critical Medicine, Nanning, 530007, China. junyulu@gxmu.edu.cn.
Xiaowen ZhengDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China. gxzhengxiaowen@163.com.
Jianfeng ZhangDepartment of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530007, China. zhangjianfeng@gxmu.edu.cn.

Funding

National Natural Science Foundation of China 82360372National Natural Science Foundation of China 82360374the Joint Project on Regional High-Incidence Diseases Research of the Guangxi Natural Science Foundation 2023GXNSFDA026023the Key Research and Development Program of Guangxi GuiKe AB22080088the Key Research and Development Program of Guangxi Guike AB23026012
6 · The paper itself

Abstract

backgroundSince the emergence of COVID-19 at the end of 2019, the disease has led to widespread acute respiratory distress syndrome (ARDS), particularly among kidney transplant recipients (KTRs), who are at increased risk due to long-term immunosuppressive therapy. This study aims to explore the differences in immune responses between kidney transplant recipients and non-kidney transplant recipients in COVID-19-induced ARDS to identify potential therapeutic targets for improving outcomes. Single-cell RNA sequencing was performed on 108,320 cells derived from peripheral blood samples to construct a global single-cell map of COVID-19 induced ARDS in kidney transplant recipients(ARDS

Indexed as

COVID-19Kidney TransplantationRespiratory Distress SyndromeAdultAgedFemaleHumansMaleMiddle AgedSARS-CoV-2Sequence Analysis, RNASingle-Cell AnalysisTransplant RecipientsARDSCOVID-19Immune microenvironmentKidney transplantationscRNA-seq

Identifiers

PMID40011702
PMCPMC11865448

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.