ArticleBMC oral health2025
5'tiRNA-35-GlyTCC-3 and 5'tiRNA-33-CysGCA-11 target BMP6, CUL1 and SPR of non-syndromic cleft palate.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Transfer RNA Fragments in Diseases of Sensory Organs.International journal of molecular sciences · 2026Review
- MiR-223-3p regulates erythropoiesis by targeting TGFBR3/Smad signaling pathway in hemoglobin H-Constant Spring disease.Annals of medicine · 2025Article
- A specific tsRNA in serum from patients with nasopharyngeal carcinoma: 5'tiRNA-32-ValAAC-2 mediates malignance of nasopharyngeal carcinoma cells.Frontiers of medicine · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundtsRNAs are novel small non-coding RNAs that play important regulatory roles in gene expression, translation, transcription, and epigenetic modification through proteins or mRNAs and may be therapeutic targets for certain diseases. The etiology of non-syndromic cleft palate-only is complex and the pathogenesis is poorly understood, non-coding RNAs play important roles in its development.
methodsThe tsRNAs of patients with simple cleft palate were compared with healthy individuals using small RNA microarray, bioinformatic analysis, quantitative real-time transcription polymerase chain reaction, and the effects measured using immunohistochemical staining.
resultsSeventy-nine tsRNAs were upregulated and fifty-four tsRNAs were downregulated in patients with simple cleft palate compared with healthy individuals, among which the expression of 5'tiRNA-35-GlyTCC-3 and 5'tiRNA-33-CysGCA-11 was markedly different and was involved in key signaling pathways related to the development of the palate, such as the cell cycle, cAMP signaling pathway, BMP signal transduction, folate biosynthesis, and other key signaling pathways that determine anatomical structure occurrence, regulate gene expression during development, influence epigenetics, and other biological processes, its target genes include BMP6, CUL1 and SPR.
conclusion5'tiRNA-35-GlyTCC-3 and 5'tiRNA-33-CysGCA-11 are closely associated with non-syndromic cleft palate development and are expected to be potential new targets for diagnosis and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.