SynthesisRenal failure2025
Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study.
Synthesis in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Botany, Phytochemistry, Pharmacology, and Application of Potentilla discolor: A Systematic Review.Chemistry & biodiversity · 2026Pooled it
- Comprehensive impact of Intermittent Hypoxia Training and Intermittent Fasting on metabolic and cognitive health in adults with obesity: an umbrella systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Urinary Extracellular Vesicle-Derived miRNAs as Regulators and Biomarkers in Diabetic Kidney Disease.International journal of molecular sciences · 2026Review
- Stage-specific risks of mortality and renal outcomes in cardiovascular-kidney-metabolic syndrome: findings from a nationwide Japanese cohort.Clinical and experimental nephrology · 2026Article
- Targeting the TFAM-cGAS-STING axis: a mitochondrial-inflammatory link in the pathogenesis and treatment of diabetic kidney disease.International urology and nephrology · 2026Review
- Development and validation of a predictive model for diabetic kidney disease risk in patients with T2DM: a hospital data platform study.Frontiers in endocrinology · 2026Article
- Risk factors and mediating mechanisms of restless legs syndrome in patients undergoing maintenance hemodialysis: a longitudinal cohort study combined with Mendelian randomization analysis.Frontiers in neurology · 2026Article
- Epidemiological trend in diabetic kidney disease (DKD) burden in China from 1990 to 2021, and projections for 2041: an analysis of the global burden of disease study 2021.BMC public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to identify major risk factors for diabetic kidney disease (DKD) and examine their causal relationships using meta-analysis and Mendelian randomization. MATERIALS AND
methodsThis study reviewed diabetic nephropathy literature up to September 2024, evaluating quality with NOS, AMSTAR 2, and JBI. It analyzed heterogeneity using the Baujat plot and leave-one-out method, and conducted meta-analysis with fixed- or random-effects models based on I
resultsMeta-analysis identified several significant risk factors for DKD, including hypertension (relative risk [RR] = 6.33), comorbidities (RR = 4.96), poor glycemic control (RR = 3.27), non-adherence to treatment (RR = 3.30), an unhealthy diet (RR = 5.96), physical inactivity (RR = 5.60), and hyperuricemia (RR = 5.24). MR analysis further confirmed a causal relationship between high carbohydrate intake (odds ratio [OR] = 1.393,
conclusionsBy integrating meta-analysis with Mendelian randomization, this study provides robust evidence linking modifiable risk factors, particularly dietary habits and lifestyle behaviors, to DKD development. The findings highlight the need for early preventive strategies targeting glycemic control, hypertension, and dietary modifications to mitigate DKD progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.