Evidence map›Paper›PMID 40012485›Full record

ArticleACS applied bio materials2025

Biological Augmentation Using Electrospun Constructs with Dual Growth Factor Release for Rotator Cuff Repair.

Yaping Ding, Yao Huang, Fucheng Zhang, Lei Wang, Wei Li, Hélder A Santos, Luning Sun

Abstract read
In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaping DingNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China.
Yao HuangDepartment of Orthopedics, Sports Medicine Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Fucheng ZhangDepartment of Orthopedics, Sports Medicine Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Lei WangDepartment of Orthopedics, Sports Medicine Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.
Wei LiDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0002-6997-9611
Hélder A SantosDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0001-7850-6309
Luning SunDepartment of Orthopedics, Sports Medicine Center, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Surgical reattachment of tendon to bone is the standard therapy for rotator cuff tear (RCT), but its effectiveness is compromised by retear rates of up to 94%, primarily due to challenges in achieving successful tendon-bone enthesis regeneration under natural conditions. Biological augmentation using biomaterials has emerged as a promising approach to address this challenge. In this study, a bilayer construct incorporates polydopamine (PDA)-mediated bone morphogenetic protein 2 (BMP2) and BMP12 in separate poly(lactic-

Indexed as

Biocompatible MaterialsBone Morphogenetic Protein 2Rotator Cuff InjuriesTissue ScaffoldsAnimalsHumansIndolesMaterials TestingParticle SizePolylactic Acid-Polyglycolic Acid CopolymerPolymersRats, Sprague-DawleyRotator CuffBiocompatible MaterialsBone Morphogenetic Protein 2IndolespolydopaminePolylactic Acid-Polyglycolic Acid CopolymerPolymersbilayer structureelectrospinninggrowth factorsrotator cuff teartendon-bone interfaces

Identifiers

PMID40012485
PMCPMC11921024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.