ArticleBrain circulation
Cerebral blood flow change with fluid resuscitation in acute ischemic stroke.
Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02056821 (Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding Drug Interactions in Antiplatelet Therapy for Atherosclerotic Vascular Disease: A Systematic Review.CNS neuroscience & therapeutics · 2025Pooled it
- Cerebral blood flow alterations in non-auditory tinnitus: implications for cerebral venous congestion pathophysiology.Brain imaging and behavior · 2026Article
- Revisiting Incomplete Tissue-Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke.Annals of neurology · 2026Review
- Cerebral small vessel disease impairs dynamic cerebral autoregulation and mediates outcomes after stroke thrombectomy.Therapeutic advances in neurological disorders · 2026Article
- Review
- A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial.BMC medicine · 2025Article
- Therapeutic potential of natural products in ischemic stroke: targeting angiogenesis.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn acute ischemic stroke (AIS), cerebral autoregulation becomes dysfunctional, impacting the brain's ability to maintain cerebral blood flow (CBF) at adequate levels. Reperfusion of affected and nearby brain tissue in AIS is currently the aim of treatment in AIS, but the effectiveness of fluid resuscitation on increasing the CBF is debated.
objectiveWe investigated the hypothesis that early fluid resuscitation with normal saline bolus would improve CBF velocity in the initial resuscitation of patients with AIS.
methodsWe conducted a prospective, quasi-experimental study on 30 patients in the early stages of AIS management. Patients had a National Institutes of Health Stroke Scale (NIHSS) score of 3 or higher. Patients met inclusion criteria if they were 18-90 years old and had time of stroke onset within 12 h. Patients with a severe underlying disability, hemorrhagic stroke, advanced directives for comfort care/hospice, as well as pregnant patients were excluded. Noninvasive hemodynamic monitoring was performed. We performed transcranial Doppler (TCD) insonation of the middle cerebral arteries (MCAs) to measure CBF velocity. Each patient received a 500-ml normal saline crystalloid bolus as a standardized intervention, then had hemodynamic and TCD measurements repeated. Analysis was limited to patients with stroke confirmed with neuroimaging. Mean flow velocity (MFV) was compared before and postreceiving the bolus in the MCA ipsilateral to the ischemic location.
resultsThirty patients were analyzed who had confirmed AIS. The mean age was 53 ± 13 years, 50% were female, and the median NIHSS was 6 (interquartile range: 4-7). Outcomes measured included various cerebrovascular and cardiovascular parameters. Infusion of 500-mL normal saline bolus produced increases in systolic blood pressure (+7 mmHg, 95% confidence interval [CI] 0.6-13 mmHg) and stroke volume (SV) index (+2.2 ml/m
conclusionOur prospective study of AIS patients revealed that a fluid bolus improves hemodynamic parameters, but did not significantly increase CBF velocity.
trial registrationclinicaltrials.gov (identifier: NCT02056821).
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