ArticleJournal of child psychology and psychiatry, and allied disciplines2025
The association between temperament and polygenic score for psychopathology from infancy to middle childhood.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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8 authors.
Funding
Abstract
backgroundCertain temperament characteristics, such as low effortful control and high negative affectivity, are linked to an elevated likelihood for later psychopathology. Although genetic vulnerability has been associated with a number of psychiatric conditions, little work has examined the genetic architecture underlying temperament or the genetic overlap between early temperament profiles and later mental health outcomes. The present study examined associations of polygenic scores for anxiety (PGS-Anxiety) and ADHD (PGS-ADHD) with temperament characteristics in a longitudinal sample of children assessed from infancy through age 7 years.
methodsAnalyses were conducted in a sample of children (European Ancestry n = 476; Full Sample [European and other ancestries] N = 606).
resultsWe observed an age-by-PGS interaction on effortful control. As children aged, there appeared to be stronger negative associations between PGS-ADHD and effortful control. No associations were observed between PGS-Anxiety and negative affectivity.
conclusionsOverall, the findings suggest some support for associations between genetic underpinnings for externalizing psychopathology and temperament that increase over time.
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