ArticleAngewandte Chemie (International ed. in English)2025
Site-Selective C─H Bond Functionalization of Sugars.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Photocatalytic Site- and Stereoselective Functionalization of Carbohydrates.Chemical record (New York, N.Y.) · 2026Review
- Site-Selective Distal Arylation of Sugars Enabled by Cyclic Acetals.Journal of the American Chemical Society · 2026Article
- Catalytic Strategies for Stereoselective Carbohydrate Synthesis: Emerging Concepts for Accessing Challenging Glycosides.Angewandte Chemie (International ed. in English) · 2025Review
- Site-Selective C─H Bond Functionalization of Sugars.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Non-typical C-functionalized sugars represent a prominent yet hardly accessible class of biologically-active compounds. The available synthetic methodologies toward such sugar derivatives suffer either from an extensive use of protecting groups, requiring long and laborious synthetic manipulations, or from limited predictability and noncontrollable site-selectivity of the employed C-functionalization reactions. In this work, we disclose an alternative synthetic methodology toward nontypical sugars that allows facile, site-selective, and stereocontrolled C-functionalization of sugars through a traceless tethering approach. The described silyl-based redox-active tethering group appends directly to the unprotected sugar substrate and mediates the C-functionalization reaction through a photochemically-promoted 1,6-hydrogen atom transfer (HAT) mechanism, while transforming into a readily-removable silyl protecting group. The protocol is compatible with a variety of unprotected carbohydrate substrates featuring sensitive aglycons and a diverse set of coupling partners, providing a straightforward and scalable route to pharmaceutically relevant C-functionalized carbohydrate conjugates.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.