Evidence map›Paper›PMID 40013825›Full record

ArticlemSystems2025

Revealing pathogenesis-associated metabolites in

Adrian Heckart, Jean-Christophe Cocuron, Stephanie C Ray, Chad A Rappleye, Ana P Alonso

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Metabolomic signaling in sarcoidosis pathogenesis.Current opinion in immunology · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adrian HeckartDepartment of Biological Sciences & BioDiscovery Institute, University of North Texas, Denton, Texas, USA.ORCID 0009-0001-7193-3671
Jean-Christophe CocuronBioAnalytical Facility, University of North Texas, Denton, Texas, USA.
Stephanie C RayDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.
Chad A RappleyeDepartment of Microbiology, The Ohio State University, Columbus, Ohio, USA.ORCID 0000-0001-7880-5958
Ana P AlonsoDepartment of Biological Sciences & BioDiscovery Institute, University of North Texas, Denton, Texas, USA.ORCID 0000-0003-4696-1811

Funding

Intracellular Proliferation of the fungal pathogen Histoplasma capsulatumR01AI148561 · NIAID · OHIO STATE UNIVERSITY · PI Chad A Rappleye · 2020 to 2026
$2.5M
NIAID NIH HHS R01 AI148561NIH HHS R01-AI148561
6 · The paper itself

Abstract

During infection,

Indexed as

HistoplasmaHistoplasmosisMetabolomeMetabolomicsAnimalsHumansMacrophagesMicefungal pathogenHistoplasmahistoplasmosishost–pathogenmass spectrometrymetabolomics

Identifiers

PMID40013825
PMCPMC11915866

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.