ArticleArchives of dermatological research2025
Oxidative stress mediated by the NOX2/ROS/NF-κB signaling axis is involved in rosacea.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular Mechanisms in the Etiopathology of Rosacea-Systematic Review.International journal of molecular sciences · 2025Pooled it
- Dicranum scoparium extract modulates the NOX2/SOD2 axis and NF-κB signaling in a fibroblast-macrophage co-culture model.Molecular biology reports · 2026Article
- Systemic Inflammatory and Oxidative-Metabolic Alterations in Rosacea: A Cross-Sectional Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- Objective assessment of rosacea erythema severity: a multimodal artificial intelligence framework integrating VISIA® imaging and image-derived tabular features.Frontiers in medicine · 2026Article
- Neuro-immune-vascular interactions in rosacea and hypertension: a mechanistic review.Frontiers in immunology · 2026Review
- Lithospermic acid, a novel KLK5 inhibitor, ameliorates rosacea by suppressing the TLR4/NF-κB signaling pathway and rectifying phenylalanine metabolism.Frontiers in immunology · 2026Article
- Integrated Genomic and GEO Data Analysis Reveals Therapeutic Targets for Rosacea.Journal of cosmetic dermatology · 2025Article
- Updates in the Treatment of Rosacea with γ-Aminobutyric Acid Derivatives.Clinical, cosmetic and investigational dermatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosacea is a chronic inflammatory cutaneous disease characterized by a multifaceted pathogenesis. Extensive research has demonstrated that oxidative stress plays a pivotal role in the etiology of rosacea, mediating vascular alterations and inflammation cascades via the generation of reactive oxygen species (ROS). Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) possesses the capacity to synthesize ROS and exhibits a strong correlation with diverse inflammatory processes. However, the effects of NOX2 in rosacea are unknown. Our findings revealed that NOX2 was highly expressed in rosacea. Inhibition of NOX2 improved markedly rosacea-like manifestations, encompassing reduced skin erythema and downregulated expression of pro-inflammatory cytokines and chemokines. Additionally, knockdown NOX2 in HaCaT keratinocytes significantly rescues TNF-α-induced oxidative stress and inflammation. Our study further elucidated that inhibition of NOX2 suppressed NF-κB activation in LL37-induced skin and LL37/ TNF-α-induced HaCaT keratinocytes. Our results demonstrate that NOX2 plays a proinflammatory role in rosacea by regulating the NF-κB signaling pathway.
Indexed as
Identifiers
40014137What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.