Evidence map›Paper›PMID 40014573›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration.

Pabitra K Sahoo, Manasi Agrawal, Nicholas Hanovice, Patricia J Ward, Meghal Desai, Terika P Smith, HaoMin SiMa, Jennifer N Dulin, Lauren S Vaughn, Mark H Tuszynski and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Peptide-Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Subcellular mass spectrometry reveals proteome remodeling in an asymmetrically dividing (frog) embryonic stem cell.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Stress Granules as Molecular Echoes of Gut Inflammation.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  7. Pharmacological modulation of stress granulesFrontiers in pharmacology · 2026
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Pabitra K SahooDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.ORCID 0000-0002-1076-9409
Manasi AgrawalDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.ORCID 0000-0002-1274-6032
Nicholas HanoviceDepartments of Neurosurgery and Ophthalmology, Boston Children's Hospital, Cambridge, MA 02115.ORCID 0000-0003-0827-6071
Patricia J WardDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, GA 30332.
Meghal DesaiDepartment of Biological Sciences, Rutgers University-Newark, Newark, NJ 07102.ORCID 0000-0002-4076-6049
Terika P SmithDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.
HaoMin SiMaDepartments of Neurosurgery and Ophthalmology, Boston Children's Hospital, Cambridge, MA 02115.ORCID 0009-0001-3604-9768
Jennifer N DulinDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093.ORCID 0000-0001-5767-4290
Lauren S VaughnDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.ORCID 0000-0003-2282-6738
Mark H TuszynskiDepartment of Neurosciences, University of California-San Diego, La Jolla, CA 92093.
Kristy WelshhansDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.ORCID 0000-0001-6624-4719
Larry I BenowitzDepartments of Neurosurgery and Ophthalmology, Boston Children's Hospital, Cambridge, MA 02115.ORCID 0000-0002-0277-7222
Arthur W EnglishDepartment of Cell Biology, School of Medicine, Emory University, Atlanta, GA 30332.ORCID 0000-0002-5116-5871
John D HouleDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129.ORCID 0000-0002-3266-9185
Jeffery L TwissDepartment of Biological Sciences, University of South Carolina, Columbia, SC 29208.ORCID 0000-0001-7875-6682

Funding

Role of Stress Granule Protein Aggregation in Axon RegenerationR01NS117821 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2020 to 2024
$2.8M
Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF) N/AGeorge W. Neilson Foundation 733151HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01-NS0117821Merkin Peripheral Neuropathy and Nerve Regeneration Center N/ANINDS NIH HHS R01 NS117821South Carolina Spinal Cord Injury Research Fund (SCIRF) N/AUniversity of South Carolina Vice President for Research Office N/A
6 · The paper itself

Abstract

Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in

Indexed as

AxonsCentral Nervous SystemDNA HelicasesNerve RegenerationPeripheral Nerve InjuriesPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsAnimalsHumansMiceRatsDNA HelicasesG3BP1 protein, humanG3bp1 protein, mousePoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif Proteinsaxon regenerationCNS injuryG3BP1local protein synthesisstress granules

Identifiers

PMID40014573
PMCPMC11892601

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.