ArticlePloS one2025
Risk factors for osteoporosis in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Managing Bone Fragility in Older Adults with Diabetes: Pathophysiology, Assessment, and Therapeutic Considerations.Drugs & aging · 2026Review
- Osteoporosis in Patients with Pre-Existing Diabetes Mellitus and in Women with Estrogen Deficiency: A Molecular and Cellular Perspective.International journal of molecular sciences · 2026Review
- 10-Year Fracture Risk Assessment with Novel Adjustment (FRAXplus): Type 2 Diabetic Sample-Focused Analysis.Diagnostics (Basel, Switzerland) · 2025Article
- Analysis of the Current Status of Self-Management Behaviors and Factors Affecting Self-Management in Elderly Empty Nesters with Comorbid Hypertension and Type 2 Diabetes Mellitus, a Cross-Sectional Study From the Community.Risk management and healthcare policy · 2025Article
- Multidimensional dietary assessment and interpretable machine learning models predict the risk of prediabetes/diabetes and osteoporosis comorbidity in older adults.Frontiers in nutrition · 2025Article
- Diabetes-Associated Risk and Population Burden of Comorbid Conditions Among Older Adults and Elderly Persons in India.Sage open agingArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis is a prevalent chronic result of diabetes. Osteoporosis susceptibility is raised by unstable blood glucose levels, oxidative stress, hormonal abnormalities, and other factors. Currently, there is no systematic review addressing the risk factors of osteoporosis in diabetes. This study intends to systematically assess the current risk factors related to diabetic osteoporosis (DOP) and provide suggestions for the improvement of therapy approaches. METHODS AND ANALYSIS: We will search five English literature databases (PubMed, Embase, Web of Science, CINAHL, and Cochrane Library) and three Chinese databases (CNKI, WanFang, and SinoMed) from the starting point until December 31, 2024. We will perform a systematic examination and meta-analysis of cohort and case-control studies to identify all population-based risk factors for diabetic osteoporosis. Two researchers will independently assess the publication, extract data, and evaluate the quality and potential biases present in the study. We will utilize RevMan V.5.4 software and STATA 16.0 for data analysis. The included studies will be assessed using the Newcastle Ottawa Quality Assessment Instrument (NOS). If the heterogeneity of the included studies is higher than 50%, we will perform subgroup and sensitivity analysis to identify probable sources of heterogeneity. The assessment of publication bias will be conducted using funnel plot. Furthermore, we will employ the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to assess the quality of evidence for each exposure and outcome. DISCUSSION: This protocol aims to investigate the risk variables associated with DOP. We will summarize the current knowledge about factors influencing osteoporosis in diabetes. We strive to assist physicians with more extensive references for decision-making and facilitate the implementation of effective prevention strategies for DOP. REGISTRATION: This study has been registered in the PROSPERO (CRD42024602637).
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