Evidence map›Paper›PMID 40015754›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

Protocol for an intergenerational randomized controlled trial to enhance physical activity in older adults at risk for Alzheimer's disease.

Caitlin S Walker, Adrián E Noriega de la Colina, Linda Li, Carolynn Boulanger, Nagashree Thovinakere, Alix Noly-Gandon, Garance Barnoin, Mitchell Bennett, Jillian Caplan, Laurence Côté and 18 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. The PREVENT-AD cohort: Accelerating Alzheimer's disease research and treatment in Canada and beyond.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Caitlin S WalkerMontreal Neurological Institute-Hospital Cognitive Neuroscience Research Group, McGill University, Montreal, QC, Canada. Electronic address: caitlin.walker@mail.mcgill.ca.
Adrián E Noriega de la ColinaThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Massachusetts Institute of Technology, Cambridge, MA, USA; McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Linda LiDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada.
Carolynn BoulangerFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Nagashree ThovinakereThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada; Rotman Research Institute, University of Toronto, Toronto, Canada.
Alix Noly-GandonThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Garance BarnoinDepartment of Arts and Science, McGill University, Montreal, QC, Canada.
Mitchell BennettDepartment of Arts and Science, McGill University, Montreal, QC, Canada.
Jillian CaplanFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Laurence CôtéFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Sarah ElbazFaculty of Medicine, Laval University, Quebec City, QC, Canada.
Shania Fock Ka BaoFaculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
Ryan KaraThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Nicolas LavoieFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Maggie NguyenFaculty of Pharmacy, Université de Montréal, Montreal, QC, Canada.
Franciska OtanerFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Helen Pallett-WieselSchool of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Johanie Victoria PichéFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Andreanne PowersFaculty of Medicine, Laval University, Quebec City, QC, Canada.
Sofia RicciardelliFaculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Kayla WilliamsThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Christine DéryCentre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Jennifer Tremblay-MercierCentre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada.
Judes PoirierCentre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Sylvia VilleneuveThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; McConnell Brain Imaging Centre (BIC), MNI, Faculty of Medicine, McGill University, Montreal, QC, Canada; McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada.
Arthur F KramerCenter for Cognitive & Brain Health, Northeastern University, Boston, MA, USA; Beckman Institute, University of Illinois, Urbana, Illinois, USA.
Maiya R GeddesThe Neuro, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, QC, Canada; Centre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada; Massachusetts Institute of Technology, Cambridge, MA, USA; McGill University Research Centre for Studies in Aging, McGill University, Montreal, QC, Canada; Center for Cognitive & Brain Health, Northeastern University, Boston, MA, USA; Rotman Research Institute, University of Toronto, Toronto, Canada.
PREVENT-AD Research GroupCentre for Studies in the Prevention of Alzheimer's Disease, Douglas Mental Health Institute, McGill University, Montreal, QC, Canada.

Funding

Core B - Pilot StudiesP30AG048785 · NIA · BRANDEIS UNIVERSITY · PI LACHMAN, MARGIE E · 2014 to 2023
$4.5M
NIA NIH HHS P30 AG048785
6 · The paper itself

Abstract

backgroundPhysical inactivity is one of the most important modifiable risk factors for Alzheimer's disease in North America. Despite this, most older adults are physically inactive. It is currently unknown how to successfully motivate physical activity behavior in older adults at risk for Alzheimer's disease, and this knowledge is crucial for early and effective disease prevention. Prior research has shown that intergenerational social engagement and prosocial behaviours can enhance the health and well-being of older adults.

objectivesThis manuscript describes the design of a randomized controlled trial that will test the efficacy of a behavioral intervention to enhance physical activity in older adults at risk for Alzheimer's disease. DESIGN/

settingThis is a single-blinded, two-arm stratified randomized controlled trial that incorporates a hybrid efficacy and implementation design. Participants are randomized to an intervention or control condition in a 1:1 ratio and are stratified by a multimodal Alzheimer's disease risk score. All study visits are conducted remotely through videoconferencing.

participantsThe study aims to recruit 60 older adults with a first-degree family history of Alzheimer's disease from the PREVENT-AD cohort and 30 younger adults who are paired with older adults in the intervention condition.

interventionOlder participants in the intervention group will be paired with younger study partners and receive positive, daily messages over four weeks using a novel technology platform. The daily messages combine intergenerational social engagement (growing a virtual garden with a younger study partner) and prosocial goals (donations to charity after reaching step count goals). MEASUREMENTS: The primary outcome is change in step count compared to baseline measured using a wrist-worn triaxial accelerometer. Secondary outcomes include time spent physically active, mood, generativity, loneliness, and cognition. Target mechanisms (social support and generativity) of physical activity engagement will be examined. Ease of use, acceptability, and feasibility of the technology as well as barriers and facilitators of participation will be assessed.

conclusionsThis research will advance our understanding of mechanisms and individual differences underlying successful physical activity engagement in older adults who are at risk for Alzheimer's disease. This knowledge will contribute to strategies for promoting health behaviours that can prevent the risk of Alzheimer's disease.

Indexed as

Alzheimer DiseaseExerciseAgedFemaleHumansMaleRandomized Controlled Trials as TopicRisk FactorsSingle-Blind MethodAlzheimer's diseasebehavioral interventionclinical trialintergenerationalphysical activity

Identifiers

PMID40015754
PMCPMC11868723

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.