Evidence map›Paper›PMID 40015916›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Molecular Imaging of Pulmonary Fibrosis.

Margaret B Allison, Ciprian Catana, Iris Y Zhou, Peter Caravan, Sydney B Montesi

Abstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Mechanobiology and Resolution of Lung Fibrosis.Annual review of physiology · 2026
    Review
  3. Review
  4. Review
  5. Assessment of the Diagnostic Value of [Diagnostics (Basel, Switzerland) · 2025
    Article
  6. EJNMMI research · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Margaret B AllisonDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Ciprian CatanaDepartment of Radiology, Harvard Medical School, Boston, Massachusetts.
Iris Y ZhouDepartment of Radiology, Harvard Medical School, Boston, Massachusetts.
Peter CaravanDepartment of Radiology, Harvard Medical School, Boston, Massachusetts.
Sydney B MontesiDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts; sbmontesi@mgb.org.

Funding

PET-MR Imaging of pulmonary fibrosisR01HL153606 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, CATANA, CIPRIAN · 2021 to 2025
$4.1M
PET Imaging of Pulmonary FibrosisR01HL131907 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D, LANUTI, MICHAEL · 2016 to 2018
$2.3M
Advanced Imaging for Pulmonary FibrosisR01HL171240 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Sydney Montesi · 2024 to 2026
$1.8M
PET Imaging of Pulmonary FibrosisR01HL116315 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2012 to 2014
$1.3M
Optimization of PET probe for imaging lung fibrogenesisR33HL154125 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2020 to 2021
$1.2M
Vascular Leak and Outcomes in IPFK23HL150331 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MONTESI, SYDNEY · 2020 to 2024
$887k
Quantitative MRI-PET Imaging of Pulmonary FibrosisK25HL148837 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ZHOU, IRIS YUWEN · 2020 to 2023
$686k
Automation Equipment for Human PET Radiotracer ProductionS10OD028499 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2021 to 2021
$325k
NHLBI NIH HHS K23 HL150331NHLBI NIH HHS K25 HL148837NHLBI NIH HHS R01 HL116315NHLBI NIH HHS R01 HL131907NHLBI NIH HHS R01 HL153606NHLBI NIH HHS R01 HL171240NHLBI NIH HHS R33 HL154125NIH HHS S10 OD028499
6 · The paper itself

Abstract

Fibrosing lung diseases affect over 160,000 individuals in the United States alone and can carry a prognosis that is worse than many cancers. Antifibrotic treatments modify only the rate of fibrosis progression, and more effective therapies are urgently needed. Molecular imaging enables visualization of disease pathogenesis in progress. It provides a noninvasive means to monitor and quantify dysregulated molecular fibrotic pathways and shows great promise in aiding the diagnosis and disease activity monitoring of pulmonary fibrosis. Here, we review molecular imaging probes under development for use in pulmonary fibrosis. We provide our opinion on current challenges in translating preclinical molecular imaging probes into clinical successes, as well as future directions for expanding their use in drug development.

Indexed as

Molecular ImagingPulmonary FibrosisAnimalsHumansinterstitial lung diseasemolecular imagingpulmonary fibrosis

Identifiers

PMID40015916
PMCPMC11960603

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.