Evidence map›Paper›PMID 40016130›Full record

ArticleAJNR. American journal of neuroradiology2025

Assessment of Trigeminal Nerve Root Demyelination in Patients with Primary Trigeminal Neuralgia Using Macromolecular Proton Fraction Imaging.

Elena A Filimonova, Anton A Pashkov, Vasily L Yarnykh, Maria I Schukina, Boris A Zaitsev, Azniv V Martirosyan, Galina I Moysak, Jamil A Rzaev

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In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elena A FilimonovaFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia e.filimonova@alumni.nsu.ru.ORCID 0000-0002-6696-9071
Anton A PashkovFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.ORCID 0000-0002-2403-3136
Vasily L YarnykhDepartment of Radiology (V.L.Y.), University of Washington, Seattle, Washington.ORCID 0000-0002-1583-8979
Maria I SchukinaFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.
Boris A ZaitsevFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.ORCID 0000-0002-0115-3776
Azniv V MartirosyanFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.ORCID 0009-0009-8603-3308
Galina I MoysakFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.
Jamil A RzaevFrom the FSBI "Federal Center of Neurosurgery," (E.A.F., A.A.P., M.I.S., B.A.Z., A.V.M., G.I.M., J.AR.), Novosibirsk, Russia.

Funding

Quantitative myelin mapping in vivo for clinical and pre-clinical MRIR24NS104098 · NINDS · UNIVERSITY OF WASHINGTON · PI YARNYKH, VASILY L. · 2018 to 2021
$1.1M
NINDS NIH HHS R24 NS104098
6 · The paper itself

Abstract

background and purposePrimary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder. This condition is believed to be associated with demyelination of the trigeminal nerve. Previous studies in this field have focused on diffusion tensor imaging, which has limited sensitivity and specificity to myelin. In the present study, we assessed the trigeminal nerve root via the macromolecular proton fraction (MPF) mapping technique. MPF demonstrated strong correlations with myelin histology in a number of earlier animal studies and is currently viewed as a promising clinical myelin biomarker. MATERIALS AND

methodsWe performed a prospective case-control study. Fifty-six patients with unilateral PTN and 27 healthy controls were included. All participants were evaluated by using high-resolution brain MR imaging, which included the MPF technique. MPF values from different parts of the trigeminal nerve root, such as the root entry zone (REZ) and central and lateral cisternal segments, were extracted. ANCOVAs were performed. Correlations between MPF values and Sindou grade, duration, and intensity of symptoms were also evaluated in patients with PTN.

resultsA statistically significant decrease in the average MPF of the affected trigeminal nerve root was observed in the PTN group compared with the healthy control group (

conclusionsOur preliminary results suggest that MPF could serve as a new neuroimaging biomarker of trigeminal nerve root impairment in patients with PTN and enable noninvasive detection of nerve root demyelination.

Indexed as

Demyelinating DiseasesMagnetic Resonance ImagingTrigeminal NerveTrigeminal NeuralgiaAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProspective StudiesProtonsReproducibility of ResultsSensitivity and SpecificityProtons

Identifiers

PMID40016130
PMCPMC11979799

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.